DNA methylation landscapes of human fetal development
RC Slieker, MS Roost, L van Iperen… - PLoS …, 2015 - journals.plos.org
Remodelling the methylome is a hallmark of mammalian development and cell
differentiation. However, current knowledge of DNA methylation dynamics in human tissue …
differentiation. However, current knowledge of DNA methylation dynamics in human tissue …
Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory
transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the …
transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the …
[PDF][PDF] The NOTCH1/SNAIL1/MEF2C pathway regulates growth and self-renewal in embryonal rhabdomyosarcoma
Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and
drive continued tumor growth. However, mechanisms regulating TPC self-renewal are …
drive continued tumor growth. However, mechanisms regulating TPC self-renewal are …
Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response
DP Corkery, AC Holly, S Lahsaee, G Dellaire - Nucleus, 2015 - Taylor & Francis
Alternative pre-mRNA splicing in higher eukaryotes enhances transcriptome complexity and
proteome diversity. Its regulation is mediated by a complex RNA-protein network that is …
proteome diversity. Its regulation is mediated by a complex RNA-protein network that is …
What is new in the biology and treatment of pediatric rhabdomyosarcoma?
DS Hawkins, AA Gupta… - Current opinion in …, 2014 - journals.lww.com
What is new in the biology and treatment of pediatric rhabdo... : Current Opinion in Pediatrics
What is new in the biology and treatment of pediatric rhabdomyosarcoma? : Current Opinion in …
What is new in the biology and treatment of pediatric rhabdomyosarcoma? : Current Opinion in …
Biological Role and Clinical Implications of MYOD1L122R Mutation in Rhabdomyosarcoma
D Di Carlo, J Chisholm, A Kelsey, R Alaggio… - Cancers, 2023 - mdpi.com
Simple Summary The myogenic differentiation 1 gene (MYOD1) p. L122R mutation was first
discovered in a subset of clinically aggressive rhabdomyosarcomas in both adults and …
discovered in a subset of clinically aggressive rhabdomyosarcomas in both adults and …
[HTML][HTML] DNA methylation dynamics in muscle development and disease
E Carrió, M Suelves - Frontiers in aging neuroscience, 2015 - frontiersin.org
DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …
Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS
R Ciarapica, E Carcarino, L Adesso, M De Salvo… - BMC cancer, 2014 - Springer
Abstract Background Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue
sarcoma derived from myogenic precursors that is characterized by a good prognosis in …
sarcoma derived from myogenic precursors that is characterized by a good prognosis in …
[PDF][PDF] SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state
JY Hsu, EP Danis, S Nance, JH O'Brien, AL Gustafson… - Cell reports, 2022 - cell.com
Rhabdomyosarcoma (RMS) is a pediatric muscle sarcoma characterized by expression of
the myogenic lineage transcription factors (TFs) MYOD1 and MYOG. Despite high …
the myogenic lineage transcription factors (TFs) MYOD1 and MYOG. Despite high …
Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma cells
M Zhang, B Zhu, J Davie - Journal of Biological Chemistry, 2015 - ASBMB
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Many
cellular disruptions contribute to the progression of this pediatric cancer, including aberrant …
cellular disruptions contribute to the progression of this pediatric cancer, including aberrant …