Neurofibromatosis type I (NF1) is a debilitating inherited tumor syndrome affecting around 1
in 3000 people. Patients present with a variety of tumors caused by biallelic loss of the tumor …

Rhabdomyosarcoma is a soft tissue cancer that arises in skeletal muscle due to mutations in
myogenic progenitors that lead to ineffective differentiation and malignant transformation …

Rhabdomyosarcomas (RMS) are pediatric mesenchymal-derived malignancies
encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS …

Background Rhabdomyosarcoma (RMS) is a highly malignant pediatric cancer that is the
most common form of soft tissue tumors in children. RMS cells have many features of …

DNA methylation is a key epigenetic regulatory mechanism that plays a critical role in a
variety of cellular processes, including the regulation of cell fate during development …

Rhabdomyosarcoma is a mesenchymal malignancy associated with the skeletal muscle
lineage and is also the most common pediatric soft tissue cancer. Between the two pediatric …

Despite improvement in clinical treatment of childhood cancer, it remains the leading cause
of disease-related mortality in children with survivors often suffering from treatment-related …

Over a million DNA regulatory elements have been cataloged in the human genome, but
linking these elements to the genes that they regulate remains challenging. We introduce …

The skeletal muscle is a highly plastic tissue that shows a remarkable adaptive capacity in
response to acute and resistance exercise, and modifies its composition to adapt to use and …

Skeletal myogenesis is the process of formation of the muscles that enable movement and
breathing. Muscles form after the fate determination and differentiation of precursor cells …