New insights into the neurofibroma tumor cells of origin
Neurofibromatosis type I (NF1) is a debilitating inherited tumor syndrome affecting around 1
in 3000 people. Patients present with a variety of tumors caused by biallelic loss of the tumor …
in 3000 people. Patients present with a variety of tumors caused by biallelic loss of the tumor …
[HTML][HTML] Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models
A Kahsay, E Rodriguez-Marquez, A López-Pérez… - Scientific Reports, 2022 - nature.com
Rhabdomyosarcoma is a soft tissue cancer that arises in skeletal muscle due to mutations in
myogenic progenitors that lead to ineffective differentiation and malignant transformation …
myogenic progenitors that lead to ineffective differentiation and malignant transformation …
[HTML][HTML] MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting
S Pomella, M Cassandri, L D'Archivio… - Nature …, 2023 - nature.com
Rhabdomyosarcomas (RMS) are pediatric mesenchymal-derived malignancies
encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS …
encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS …
[HTML][HTML] Loss of MEF2D expression inhibits differentiation and contributes to oncogenesis in rhabdomyosarcoma cells
M Zhang, J Truscott, J Davie - Molecular cancer, 2013 - Springer
Background Rhabdomyosarcoma (RMS) is a highly malignant pediatric cancer that is the
most common form of soft tissue tumors in children. RMS cells have many features of …
most common form of soft tissue tumors in children. RMS cells have many features of …
[HTML][HTML] Targeting DNA Methylation Machinery in Pediatric Solid Tumors
C Cristalli, K Scotlandi - Cells, 2024 - mdpi.com
DNA methylation is a key epigenetic regulatory mechanism that plays a critical role in a
variety of cellular processes, including the regulation of cell fate during development …
variety of cellular processes, including the regulation of cell fate during development …
Dysregulated myogenesis in rhabdomyosarcoma
YY Peter, DC Guttridge - Current Topics in Developmental Biology, 2018 - Elsevier
Rhabdomyosarcoma is a mesenchymal malignancy associated with the skeletal muscle
lineage and is also the most common pediatric soft tissue cancer. Between the two pediatric …
lineage and is also the most common pediatric soft tissue cancer. Between the two pediatric …
Pediatric cancer epigenome and the influence of folate
TT Yiu, W Li - Epigenomics, 2015 - Taylor & Francis
Despite improvement in clinical treatment of childhood cancer, it remains the leading cause
of disease-related mortality in children with survivors often suffering from treatment-related …
of disease-related mortality in children with survivors often suffering from treatment-related …
Chromatin accessibility dynamics of myogenesis at single cell resolution
Over a million DNA regulatory elements have been cataloged in the human genome, but
linking these elements to the genes that they regulate remains challenging. We introduce …
linking these elements to the genes that they regulate remains challenging. We introduce …
[HTML][HTML] Heat shock proteins: important helpers for the development, maintenance and regeneration of skeletal muscles
S Pomella, M Cassandri, F Antoniani, S Crotti… - Muscles, 2023 - mdpi.com
The skeletal muscle is a highly plastic tissue that shows a remarkable adaptive capacity in
response to acute and resistance exercise, and modifies its composition to adapt to use and …
response to acute and resistance exercise, and modifies its composition to adapt to use and …
Myogenesis in the genomics era
A Blais - Journal of molecular biology, 2015 - Elsevier
Skeletal myogenesis is the process of formation of the muscles that enable movement and
breathing. Muscles form after the fate determination and differentiation of precursor cells …
breathing. Muscles form after the fate determination and differentiation of precursor cells …