Droplet digital PCR of viral DNA/RNA, current progress, challenges, and future perspectives
AA Kojabad, M Farzanehpour… - Journal of Medical …, 2021 - Wiley Online Library
High‐throughput droplet‐based digital PCR (ddPCR) is a refinement of the conventional
polymerase chain reaction (PCR) methods. In ddPCR, DNA/RNA is encapsulated …
polymerase chain reaction (PCR) methods. In ddPCR, DNA/RNA is encapsulated …
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation
BEO Jensen, E Knops, L Cords, N Lübke, M Salgado… - Nature medicine, 2023 - nature.com
Despite scientific evidence originating from two patients published to date that
CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human …
CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human …
Monocyte-derived macrophages contain persistent latent HIV reservoirs
RT Veenhuis, CM Abreu, PAG Costa, EA Ferreira… - Nature …, 2023 - nature.com
The development of persistent cellular reservoirs of latent human immunodeficiency virus
(HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti …
(HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti …
Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses
HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently
considered" transcriptionally silent," but active viral gene expression may occur in some …
considered" transcriptionally silent," but active viral gene expression may occur in some …
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
NF McMyn, J Varriale, EJ Fray… - The Journal of …, 2023 - Am Soc Clin Investig
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
Combination anti-HIV antibodies provide sustained virological suppression
MC Sneller, J Blazkova, JS Justement, V Shi… - Nature, 2022 - nature.com
Antiretroviral therapy is highly effective in suppressing human immunodeficiency virus (HIV).
However, eradication of the virus in individuals with HIV has not been possible to date …
However, eradication of the virus in individuals with HIV has not been possible to date …
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
Sustained, drug-free control of HIV-1 replication is naturally achieved in less than 0.5% of
infected individuals (here termed 'elite controllers'), despite the presence of a replication …
infected individuals (here termed 'elite controllers'), despite the presence of a replication …
Prolonged viral suppression with anti-HIV-1 antibody therapy
HIV-1 infection remains a public health problem with no cure. Anti-retroviral therapy (ART) is
effective but requires lifelong drug administration owing to a stable reservoir of latent …
effective but requires lifelong drug administration owing to a stable reservoir of latent …
[HTML][HTML] COVID-19: the gendered impacts of the outbreak
The response to coronavirus disease 2019 (COVID-19) appears no different. We are not
aware of any gender analysis of the outbreak by global health institutions or governments in …
aware of any gender analysis of the outbreak by global health institutions or governments in …