Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure

MP Shakarjian, DE Heck, JP Gray, PJ Sinko… - Toxicological …, 2010 - academic.oup.com
Sulfur mustard (SM), a chemical weapon first employed during World War I, targets the skin,
eyes, and lung. It remains a significant military and civilian threat. The characteristic …

Ajulemic acid: potential treatment for chronic inflammation

SH Burstein - Pharmacology Research & Perspectives, 2018 - Wiley Online Library
Abstract Ajulemic acid (AJA, CT‐3, IP‐751, JBT‐101, anabasum) is a first‐in‐class,
synthetic, orally active, cannabinoid‐derived drug that preferentially binds to the CB2 …

[图书][B] Chemical warfare agents: chemistry, pharmacology, toxicology, and therapeutics

BJ Lukey, JA Romano Jr, JA Romano, H Salem… - 2007 - taylorfrancis.com
The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was
published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater …

Therapeutic approaches to dermatotoxicity by sulfur mustard I. Modulation of sulfur mustard‐induced cutaneous injury in the mouse ear vesicant model

RP Casillas, RC Kiser, JA Truxall… - Journal of Applied …, 2000 - Wiley Online Library
The mouse ear edema model is recognized for its usefulness in studying skin responses
and damage following exposure to chemical irritants, and for evaluating pharmacological …

Response of normal human keratinocytes to sulfur mustard: cytokine release

CM Arroyo, RJ Schafer, EM Kurt… - Journal of applied …, 2000 - Wiley Online Library
Cytokines play a major role in both acute and chronic inflammatory processes, including
those produced by sulfur mustard (2, 2′‐dichlorodiethyl sulfide, HD). This study describes …

Advances in treatment of acute sulfur mustard poisoning–a critical review

L Etemad, M Moshiri, M Balali-Mood - Critical reviews in toxicology, 2019 - Taylor & Francis
Sulfur mustard (SM) is a blistering chemical warfare agent that was used during the World
War I and in the Iraq–Iran conflict. The aim of this paper is to discuss and critically review the …

Prophylactic protection by N‐acetylcysteine against the pulmonary injury induced by 2‐chloroethyl ethyl sulfide, a mustard analogue

SK Das, S Mukherjee, MG Smith… - Journal of biochemical …, 2003 - Wiley Online Library
Mustard gas exposure causes adult respiratory distress syndrome associated with lung
injury. The purpose of this study was to investigate whether an antioxidant, such as N …

2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin

AK Jain, N Tewari-Singh, DJ Orlicky, CW White… - Toxicology, 2011 - Elsevier
Sulfur mustard (HD) is a vesicating agent that has been used as a chemical warfare agent in
a number of conflicts, posing a major threat in both military conflict and chemical terrorism …

Amelioration of sulfur mustard skin injury following a topical treatment with a mixture of a steroid and a NSAID

S Dachir, E Fishbeine, Y Meshulam… - Journal of Applied …, 2004 - Wiley Online Library
The ability to ameliorate sulfur mustard (HD)‐induced oedema by treatment with anti‐
inflammatory drugs was reported previously after screening four steroids and four non …

Matrix metalloproteinase-9 expression and release from skin fibroblasts interacting with keratinocytes: Upregulation in response to sulphur mustard

C Ries, T Popp, V Egea, K Kehe, M Jochum - Toxicology, 2009 - Elsevier
Matrix metalloproteinases (MMPs), especially MMP-9 and MMP-2, degrade various proteins
of the extracellular matrix, including collagen type IV the major component of basement …