The potential of serum neurofilament as biomarker for multiple sclerosis
Multiple sclerosis is a highly heterogeneous disease, and the detection of neuroaxonal
damage as well as its quantification is a critical step for patients. Blood-based serum …
damage as well as its quantification is a critical step for patients. Blood-based serum …
[HTML][HTML] Multiple sclerosis: mechanisms and immunotherapy
C Baecher-Allan, BJ Kaskow, HL Weiner - Neuron, 2018 - cell.com
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …
Recent advances in intelligent wearable medical devices integrating biosensing and drug delivery
The primary roles of precision medicine are to perform real‐time examination, administer on‐
demand medication, and apply instruments continuously. However, most current therapeutic …
demand medication, and apply instruments continuously. However, most current therapeutic …
Serum neurofilament light: a biomarker of neuronal damage in multiple sclerosis
Objective Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the
cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood …
cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood …
[HTML][HTML] Molecular biomarkers in multiple sclerosis
T Ziemssen, K Akgün, W Brück - Journal of neuroinflammation, 2019 - Springer
Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous
system presenting with significant inter-and intraindividual heterogeneity. However, the …
system presenting with significant inter-and intraindividual heterogeneity. However, the …
The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets
R Hohlfeld, K Dornmair, E Meinl, H Wekerle - The Lancet Neurology, 2016 - thelancet.com
Identification of the target antigens of pathogenic antibodies and T cells is of fundamental
importance for understanding the pathogenesis of multiple sclerosis, and for the …
importance for understanding the pathogenesis of multiple sclerosis, and for the …
[HTML][HTML] Vitamin D and neurological diseases: an endocrine view
C Di Somma, E Scarano, L Barrea… - International journal of …, 2017 - mdpi.com
Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and
receptors involved in genomic and non-genomic effects. In addition to classical bone-related …
receptors involved in genomic and non-genomic effects. In addition to classical bone-related …
Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod
Background: Neurofilament light chain (NFL) is a cerebrospinal fluid (CSF) marker of
neuroaxonal damage in multiple sclerosis (MS). Objective: To determine the correlation of …
neuroaxonal damage in multiple sclerosis (MS). Objective: To determine the correlation of …
NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients
S Malhotra, C Costa, H Eixarch, CW Keller, L Amman… - Brain, 2020 - academic.oup.com
Primary progressive multiple sclerosis is a poorly understood disease entity with no specific
prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity …
prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity …
[HTML][HTML] Role of Biomarkers in Risk, Diagnosis, Response to Treatment, and Prognosis of the Autoimmune Diseases
N Ghalamkarpour, AM Fard, A Babazadeh… - Kindle, 2022 - preferpub.org
Over the past three decades, many methods have been developed to evaluate levels of
biomarkers in autoimmune diseases. Early investigations have shown that some biomarkers …
biomarkers in autoimmune diseases. Early investigations have shown that some biomarkers …