Introduction The serendipitous discovery of sildenafil (Viagra [sildenafil citrate]) as a
treatment for erectile dysfunction (ED) is one of the most fascinating drug development …

Introduction The recent global outbreak of coronavirus disease 2019 (COVID-19) has
become a pandemic with a lot of sufferers. Excessive inflammation, exaggerated immune …

Real-world drug repurposing—the immediate “off-label” prescribing of drugs to address
urgent clinical needs—is a widely overlooked opportunity. Off-label prescribing (ie, for a …

Introduction Despite the ever-increasing occurrences of the coronavirus disease (COVID-19)
cases around the world, very few medications have been validated in the clinical trials to …

Background Gastric ulcer is a prevalent disease with various etiologies, including non-
steroidal anti-inflammatory drugs and alcohol consumption. This study aimed to explore the …

ABSTRACT Background Nowadays, Oral phosphodiesterase type 5 inhibitors (PDE5Is) are
widely used for the treatment of erectile dysfunction (ED). However, these drugs have …

Background Phosphodiesterase type 5 inhibitors (PDE5Is), due to their efficacy and
tolerable profile for more than 2 decades, are considered a good addition to the available …

Nitric oxide (NO) is a potent vasodilator, which improves perfusion and oxygen delivery
during tissue hypoxia in terrestrial animals. The vertebrate dive response involves …

Introduction A growing number of genetic association studies have been performed to
investigate the association between the genetic susceptibility alleles and the risk of …

Real-world drug repurposing—the immediate “off-label” prescribing of drugs to address
urgent clinical needs—is an indispensable strategy gaining rapid traction in the current …