[HTML][HTML] Malaria vaccines and the new malaria agenda
BM Greenwood, GAT Targett - Clinical Microbiology and Infection, 2011 - Elsevier
The development of an effective malaria vaccine has taken many decades, but there is now
a good chance that the first malaria vaccine will be licensed within the next few years …
a good chance that the first malaria vaccine will be licensed within the next few years …
High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in Cameroonian women living in an area of high …
YL Tutterrow, M Avril, K Singh, CA Long… - Infection and …, 2012 - Am Soc Microbiol
Placental malaria, caused by sequestration of Plasmodium falciparum-infected erythrocytes
in the placenta, is associated with increased risk of maternal morbidity and poor birth …
in the placenta, is associated with increased risk of maternal morbidity and poor birth …
Prospects and Pitfalls of Pregnancy‐Associated Malaria Vaccination Based on the Natural Immune Response to Plasmodium falciparum VAR2CSA‐Expressing …
EG Kane, AW Taylor-Robinson - Malaria Research and …, 2011 - Wiley Online Library
Pregnancy‐associated malaria, a manifestation of severe malaria, is the cause of up to
200,000 infant deaths a year, through the effects of placental insufficiency leading to growth …
200,000 infant deaths a year, through the effects of placental insufficiency leading to growth …
[HTML][HTML] Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC
A Chêne, S Gangnard, A Guadall, H Ginisty, O Leroy… - …, 2019 - thelancet.com
Background VAR2CSA is the lead antigen for developing a vaccine that would protect
pregnant women against placental malaria. A multi-system feasibility study has identified E …
pregnant women against placental malaria. A multi-system feasibility study has identified E …
[HTML][HTML] The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum
W Wang, Z Wang, X Yang, Y Gao, X Zhang, L Cao… - Cell discovery, 2021 - nature.com
Dear Editor, Pregnancy-associated malaria (PAM) threatened more than one million women
and their infants in endemic regions in 2019. This resulted in maternal anemia, stillbirth, and …
and their infants in endemic regions in 2019. This resulted in maternal anemia, stillbirth, and …
Transcriptome Analysis of Plasmodium falciparum Isolates From Benin Reveals Specific Gene Expression Associated With Cerebral Malaria
E Guillochon, J Fraering, V Joste… - The Journal of …, 2022 - academic.oup.com
Cerebral malaria (CM) is the severest form of Plasmodium falciparum infection. Children
under 5 years old are those most vulnerable to CM, and they consequently have the highest …
under 5 years old are those most vulnerable to CM, and they consequently have the highest …
[HTML][HTML] Antibody mediated activation of natural killer cells in malaria exposed pregnant women
Immune effector responses against Plasmodium falciparum include antibody-mediated
activation of innate immune cells, which can induce Fc effector functions, including antibody …
activation of innate immune cells, which can induce Fc effector functions, including antibody …
[HTML][HTML] Quantitative proteomic profiling reveals novel Plasmodium falciparum surface antigens and possible vaccine candidates
SKN Bark, R Ahmad, K Dantzler, AK Lukens… - Molecular & Cellular …, 2018 - ASBMB
Despite recent efforts toward control and elimination, malaria remains a major public health
problem worldwide. Plasmodium falciparum resistance against artemisinin, used in front line …
problem worldwide. Plasmodium falciparum resistance against artemisinin, used in front line …
Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria
EH Aitken, T Damelang, A Ortega-Pajares, A Alemu… - Elife, 2021 - elifesciences.org
Background: Plasmodium falciparum causes placental malaria, which results in adverse
outcomes for mother and child. P. falciparum-infected erythrocytes that express the parasite …
outcomes for mother and child. P. falciparum-infected erythrocytes that express the parasite …
[HTML][HTML] Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women
Background The pathogenesis of malaria in pregnancy (MiP) involves accumulation of P.
falciparum-infected red blood cells (pRBCs) in the placenta, contributing to poor pregnancy …
falciparum-infected red blood cells (pRBCs) in the placenta, contributing to poor pregnancy …