Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …

Primary lymphedema is a long-term (chronic) condition characterized by tissue lymph
retention and swelling that can affect any part of the body, although it usually develops in the …

Background Lipedema is a common adipose tissue disorder affecting women, characterized
by a symmetric subcutaneous adipose tissue deposition, particularly of the lower extremities …

Endothelial cells line blood and lymphatic vessels and form intercellular junctions, which
preserve vessel structure and integrity. The vascular endothelial cadherin, VE‐cadherin …

Light-sheet fluorescence microscopy (LSFM) can produce high-resolution tomograms of
tissue vasculature with high accuracy. However, data processing and analysis is laborious …

The lymphatic system plays a significant role in homeostasis and drainage of excess fluid
back into venous circulation. Lymphatics are also associated with a number of diseases …

Early disease diagnosis is key to the effective treatment of diseases. Histopathological
analysis of human biopsies is the gold standard to diagnose tissue alterations. However, this …

Background Recent advances in 3D imaging technologies provide novel insights to
researchers and reveal finer and more detail of examined specimen, especially in the …

Glioblastoma presents characteristically with an exuberant, poorly functional vasculature
that causes malperfusion, hypoxia and necrosis. Despite limited clinical efficacy, anti …

Biological neural networks define the brain function and intelligence of humans and other
mammals, and form ultra-large, spatial, structured graphs. Their neuronal organization is …