Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …

Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

The endoplasmic reticulum (ER) is a critical organelle, storing the majority of calcium and
governing protein translation. Thus, it is crucial to keep the homeostasis in all ER …

Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

Severe coronavirus disease 2019 (COVID-19) symptoms, including systemic inflammatory
response and multisystem organ failure, are now affecting thousands of infected patients …

Abstract Treatment of high-grade serous ovarian cancer (HGSOC) remains challenging.
Although HGSOC can potentially be responsive to immunotherapy owing to endogenous …

Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Rationale: Ferroptosis, a newly identified form of regulated cell death, can be induced
following the inhibition of cystine-glutamate antiporter system X C-because of the impaired …

Background & Aims Endoplasmic reticulum to nucleus signaling 1 (ERN1, also called
IRE1A) is a sensor of the unfolded protein response that is activated in the livers of patients …