Iron is essential for life. Many enzymes require iron for appropriate function. However,
dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species …

In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …

Halogenated organic compounds are pervasive in natural and built environments. Despite
restrictions on the production of many of these compounds in most parts of the world through …

Background Within cells, there is a narrow concentration threshold that governs whether
reactive oxygen species (ROS) induce toxicity or act as second messengers. Scope of …

The human brain generally remains structurally and functionally sound for many decades,
despite the post-mitotic and non-regenerative nature of neurons. This is testament to the …

Ayurveda is the medicinal science, dealing with utilization of naturally available plant
products for treatment. A wide variety of neuroprotective herbs have been reported in …

Organophosphorus compounds (OP) are a constant problem, both in the military and in the
civilian field, not only in the form of acute poisoning but also for their long-lasting …

Forebrain neurons have weak intrinsic antioxidant defences compared with astrocytes, but
the molecular basis and purpose of this is poorly understood. We show that early in mouse …

The failure of adult hippocampal neurogenesis is increasingly considered as an important
factor in the pathological correlates for memory decline in Alzheimer's disease (AD). Loss of …