Crystallization is one of the important unit operations for the separation and purification of
solid products in the chemical, pharmaceutical, and pesticide industries, especially for …

This work presents a framework for developing physics-informed recurrent neural network
(PIRNN) models and PIRNN-based predictive control schemes for batch crystallization …

Crystallization of active pharmaceutical ingredients (API) is one of the most important and
complex multiphase engineering operations in pharmaceutical manufacturing industry. The …

In low-and middle-income countries, the cold chain that supports vaccine storage and
distribution is vulnerable due to insufficient infrastructure and interoperable data. To bolster …

Mathematical modeling of pharmaceutical manufacturing processes can provide insights
and understanding regarding the key factors impacting product quality. In this study, we …

Fouling, encrustation, and lack of polymorphic form control are some of the major drawbacks
of continuous oscillatory baffled crystallizers (COBCs), which can lead to clogging …

Continuous crystallization of pharmaceuticals has been in the center of attention during the
past two decades, with a more focus on the large‐scale production of active pharmaceutical …

Spherical agglomeration (SA) is a process intensification strategy, which can reduce the
number of unit operations in pharmaceutical manufacturing. SA merges drug substance …

Controlled continuous crystallization of the active pharmaceutical ingredient (API)
telmisartan (TEL) has been conducted from TEL/DMSO solutions by antisolvent …

Batch cooling crystallization is a type of crystallization wherein supersaturation is brought
about by reducing the temperature of the crystallization system with time. It is commonly …