Accelerating pharmaceutical process development with an acoustic droplet ejection-multiple reaction monitoring-mass spectrometry workflow

H Hu, AN Singh, D Lehnherr, V Mdluli… - Analytical …, 2024 - ACS Publications
Fast-paced pharmaceutical process developments (eg, high-throughput experimentation,
directed evolution, and machine learning) involve the introduction of fast, sensitive, and …

On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale

T Kurdadze, F Lamadie, KA Nehme, S Teychené… - Sensors, 2024 - mdpi.com
Microfluidics has emerged as a robust technology for diverse applications, ranging from bio-
medical diagnostics to chemical analysis. Among the different characterization techniques …

Detection and Analysis of Droplets in Microfluidic devices: A Review

J Yan, J Cheng, Y Zou, J Guo, J Guo - IEEE Sensors Journal, 2024 - ieeexplore.ieee.org
Droplet microfluidics marks a significant advancement from the traditional continuous flow
systems by utilizing two non-mixing liquid phases to generate droplets for further …

Highly Localized Chemical Sampling at Subsecond Temporal Resolution Enabled with a Silicon Nanodialysis Platform at Nanoliter per Minute Flows

I Park, S Kim, CK Brenden, W Shi, H Iyer, R Bashir… - ACS …, 2024 - ACS Publications
Microdialysis (MD) is a versatile and powerful technique for chemical profiling of biological
tissues and is widely used for quantification of neurotransmitters, neuropeptides …

High‐Throughput Single‐Cell, Single‐Mitochondrial DNA Assay Using Hydrogel Droplet Microfluidics

J Park, PS Kadam, Y Atiyas, B Chhay… - Angewandte …, 2024 - Wiley Online Library
There is growing interest in understanding the biological implications of single cell
heterogeneity and heteroplasmy of mitochondrial DNA (mtDNA), but current methodologies …

[HTML][HTML] 1-Octanol-assisted ultra-small volume droplet microfluidics with nanoelectrospray ionization mass spectrometry

Y Zhao, I Park, SS Rubakhin, R Bashir, Y Vlasov… - Analytica Chimica …, 2024 - Elsevier
Background Droplet microfluidics with push-pull and microdialysis sampling from brain
slices, cultured cells and engineered tissues produce low volume mass limited samples …

Assembly of Droplet Reinjection-MS Interfaces: Overcoming Droplet Coalescence for High Throughput Screening Applications.

E Kempa, CA Smith, X Li, D Sarkar, D Morsa, R Spiess… - 2024 - chemrxiv.org
Droplet microfluidics coupled with mass spectrometry is evolving for high throughput
screening. A commercial solution that can readily interface to existing mass spectrometry …

Microfluidic assays for assessing oligonucleotide catalyst abundance and monitoring biomolecule concentration in real time

CC Douma - 2023 - search.proquest.com
Microfluidic platforms control and manipulate very small volumes of liquid, typically at the
microliter or nanoliter scale. By replacing pipettes and flasks with microfluidic channels and …