[HTML][HTML] Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
Stem-cell-based embryo models for fundamental research and translation
Despite its importance, understanding the early phases of human development has been
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …
Human neural tube morphogenesis in vitro by geometric constraints
Understanding human organ formation is a scientific challenge with far-reaching medical
implications,. Three-dimensional stem-cell cultures have provided insights into human cell …
implications,. Three-dimensional stem-cell cultures have provided insights into human cell …
Production of human spinal-cord organoids recapitulating neural-tube morphogenesis
Human spinal-cord-like tissues induced from human pluripotent stem cells are typically
insufficiently mature and do not mimic the morphological features of neurulation. Here, we …
insufficiently mature and do not mimic the morphological features of neurulation. Here, we …
[HTML][HTML] Primate gastrulation and early organogenesis at single-cell resolution
J Zhai, J Guo, H Wan, L Qi, L Liu, Z Xiao, L Yan… - Nature, 2022 - nature.com
Our understanding of human early development is severely hampered by limited access to
embryonic tissues. Due to their close evolutionary relationship with humans, nonhuman …
embryonic tissues. Due to their close evolutionary relationship with humans, nonhuman …
[HTML][HTML] Human embryonic development: from peri-implantation to gastrulation
J Zhai, Z Xiao, Y Wang, H Wang - Trends in cell biology, 2022 - cell.com
The basic body plan of the mammalian embryo is established through gastrulation, a pivotal
early postimplantation event during which the three major germ layers (endoderm …
early postimplantation event during which the three major germ layers (endoderm …
[HTML][HTML] Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines
Summary The ISSCR Guidelines for Stem Cell Research and Clinical Translation were last
revised in 2016. Since then, rapid progress has been made in research areas related to in …
revised in 2016. Since then, rapid progress has been made in research areas related to in …
Vascularization of human brain organoids
TK Matsui, Y Tsuru, K Hasegawa, K Kuwako - Stem Cells, 2021 - academic.oup.com
Human brain organoids are three-dimensional tissues that are generated in vitro from
pluripotent stem cells and recapitulate the early development of the human brain. Brain …
pluripotent stem cells and recapitulate the early development of the human brain. Brain …
[HTML][HTML] Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture
J Zhai, Y Xu, H Wan, R Yan, J Guo, R Skory, L Yan… - Cell, 2023 - cell.com
Neural tube (NT) defects arise from abnormal neurulation and result in the most common
birth defects worldwide. Yet, mechanisms of primate neurulation remain largely unknown …
birth defects worldwide. Yet, mechanisms of primate neurulation remain largely unknown …
Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications
MC Decarli, R Amaral, DP Dos Santos, LB Tofani… - …, 2021 - iopscience.iop.org
Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …