Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

Introduction The resistance-nodulation-division (RND) family is the most important group of
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …

Collateral sensitivity (CS) is an evolutionary trade-off traditionally linked to the mutational
acquisition of antibiotic resistance (AR). However, AR can be temporally induced, and the …

As recognized by several international agencies, antibiotic resistance is nowadays one of
the most relevant problems for human health. While this problem was alleviated with the …

Laboratory evolution studies, particularly with Escherichia coli, have yielded invaluable
insights into the mechanisms of antimicrobial resistance (AMR). Recent investigations have …

Different international agencies recognize that antibiotic resistance is one of the most severe
human health problems that humankind is facing. Traditionally, the introduction of new …

Pseudomonas aeruginosa is an opportunistic pathogen which causes chronic, drug-
resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of …

Understanding the consequences in bacterial physiology of the acquisition of drug
resistance is needed to identify and exploit the weaknesses derived from it. One of them is …