The role of the NLRP3 inflammasome and programmed cell death in acute liver injury

C Yu, P Chen, L Miao, G Di - International Journal of Molecular Sciences, 2023 - mdpi.com
Acute liver injury (ALI) is a globally important public health issue that, when severe, rapidly
progresses to acute liver failure, seriously compromising the life safety of patients. The …

Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation

H Li, Q Weng, S Gong, W Zhang, J Wang, Y Huang… - Food & Function, 2023 - pubs.rsc.org
Acetaminophen (APAP)-induced liver injury (AILI) has become a growing public health
problem. Ferroptosis, an iron-dependent form of cell death associated with lipid peroxide …

The dual role of immune response in acetaminophen hepatotoxicity: Implication for immune pharmacological targets

L Gong, L Liao, X Dai, X Xue, C Peng, Y Li - Toxicology Letters, 2021 - Elsevier
Acetaminophen (APAP), one of the most widely used antipyretic and analgesic drugs,
principally contributes to drug-induced liver injury when taken at a high dose. APAP-induced …

Protective effect of Que Zui tea hot-water and aqueous ethanol extract against acetaminophen-induced liver injury in mice via inhibition of oxidative stress …

Y Wang, L Tian, Y Wang, T Zhao, A Khan, Y Wang… - Food & Function, 2021 - pubs.rsc.org
The tender leaves and buds of Vaccinium dunalianum Wight have been traditionally
processed as folk tea, known as Que Zui tea (QT), with a wide range of benefits to humans …

Inspired epigenetic modulation synergy with adenosine inhibition elicits pyroptosis and potentiates cancer immunotherapy

H Xiong, X Ma, X Wang, W Su, L Wu… - Advanced Functional …, 2021 - Wiley Online Library
Overcoming innate or adaptive resistance to immune checkpoint inhibitor therapy in solid
tumors with limited T‐cell responses remains challenging. Increasing evidence has …

Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPARα to activate the NF-κB signaling pathway, thereby reducing liver injury via inducing gut …

L Kong, J Chen, X Ji, Q Qin, H Yang, D Liu, D Li… - Journal of Experimental …, 2021 - Springer
Background Alcohol-induced intestinal dysbiosis disrupts and inflammatory responses are
essential in the development of alcoholic fatty liver disease (AFLD). Here, we investigated …

Sanghuangporus sanghuang Mycelium Prevents Paracetamol-Induced Hepatotoxicity through Regulating the MAPK/NF-κB, Keap1/Nrf2/HO-1, TLR4/PI3K/Akt, and …

WP Jiang, JS Deng, SS Huang, SH Wu, CC Chen… - Antioxidants, 2021 - mdpi.com
Liver damage induced by paracetamol overdose is the main cause of acute liver failure
worldwide. In order to study the hepatoprotective effect of Sanghuangporus sanghuang …

Protective effects of E Se tea extracts against alcoholic fatty liver disease induced by high fat/alcohol diet: In vivo biological evaluation and molecular docking study

Y Wang, Z Fan, M Yang, Y Wang, J Cao, A Khan, Y Liu… - Phytomedicine, 2022 - Elsevier
Background: With the development of economy and increased workload, chronic a high-
fat/alcohol diet intake may lead to alcoholic fatty liver disease (AFLD), which is considered …

Guavinoside B from Psidium guajava alleviates acetaminophen-induced liver injury via regulating the Nrf2 and JNK signaling pathways

Y Li, J Xu, D Li, H Ma, Y Mu, X Huang, L Li - Food & function, 2020 - pubs.rsc.org
Benzophenone glycosides are a major type of polyphenols present in guava. To date, there
is still poor understanding of the relationship between benzophenone glycosides and the …

Hydrogen-rich water mitigates LPS-induced chronic intestinal inflammatory response in rats via Nrf-2 and NF-κB signaling pathways

J Peng, Q He, S Li, T Liu, J Zhang - Veterinary Sciences, 2022 - mdpi.com
Simple Summary Our study provides substantial evidence that hydrogen-rich water can
prevent intestinal damage caused by LPS-induced stimulation. Intestinal injury caused by …