Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …

The air that we breathe contains nearly 21% oxygen, most of which is utilized by
mitochondria during respiration. While we cannot live without it, it was perceived as a bane …

Mitochondria produce nitric oxide (NO) through a Ca 2+-sensitive mitochondrial NO
synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen …

▪ Abstract Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates
significant and diverse signaling functions in nearly every organ system in the body. The …

The Arabidopsis thaliana protein nitric oxide synthase1 (NOS1) is needed for nitric oxide
(NO) synthesis and signaling during defense responses, hormonal signaling, and flowering …

Accumulating evidence suggests that activation of proinflammatory M1-type macrophages in
the synovium plays a vital role in the progression of osteoarthritis (OA). Redundant nitric …