AKI associated with cardiac surgery

RH Thiele, JM Isbell, MH Rosner - Clinical Journal of the …, 2015 - journals.lww.com
Approximately 18% of patients undergoing cardiac surgery experience AKI (on the basis of
modern standardized definitions of AKI), and approximately 2%–6% will require …

Acute kidney injury associated with cardiac surgery

MH Rosner, MD Okusa - Clinical journal of the American Society …, 2006 - journals.lww.com
Acute renal failure (ARF) occurs in up to 30% of patients who undergo cardiac surgery, with
dialysis being required in approximately 1% of all patients. The development of ARF is …

Perioperative dexmedetomidine improves outcomes of cardiac surgery

F Ji, Z Li, H Nguyen, N Young, P Shi, N Fleming, H Liu - Circulation, 2013 - Am Heart Assoc
Background—Cardiac surgery is associated with a high risk of cardiovascular and other
complications that translate into increased mortality and healthcare costs. This retrospective …

[HTML][HTML] Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice

J Gu, P Sun, H Zhao, HR Watts, RD Sanders… - Critical care, 2011 - Springer
Introduction Acute kidney injury following surgery incurs significant mortality with no proven
preventative therapy. We investigated whether the α 2 adrenoceptor agonist …

ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens

DL Herr, STJ Sum-Ping, M England - Journal of cardiothoracic and …, 2003 - Elsevier
Objective: To compare dexmedetomidine-based to propofol-based sedation after coronary
artery bypass graft (CABG) surgery in the intensive care unit (ICU). Design: Randomized …

Dexmedetomidine: sedation, analgesia and beyond

C Chrysostomou, CG Schmitt - Expert opinion on drug metabolism …, 2008 - Taylor & Francis
Background: Dexmedetomidine is an α-2 adrenoreceptor agonist with sedative, analgesic
and anxiolytic properties. Since its release in the US market in late 1999, it has gained …

[HTML][HTML] Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery

JS Cho, JK Shim, S Soh, MK Kim, YL Kwak - Kidney international, 2016 - Elsevier
Acute kidney injury (AKI) following cardiac surgery is closely interrelated with hemodynamic
instability and sympathetic activity, and adversely influences prognosis. Here, we …

A prospective randomized study of the potential benefits of thoracic epidural anesthesia and analgesia in patients undergoing coronary artery bypass grafting

NB Scott, DJ Turfrey, DAA Ray, O Nzewi… - Anesthesia & …, 2001 - journals.lww.com
IMPLICATIONS: Many anesthesiologists believe that thoracic epidural anesthesia/analgesia
(TEA) is contraindicated for cardiac surgery because of increased risk of paraplegia …

Interventions for protecting renal function in the perioperative period

M Zacharias, M Mugawar, GP Herbison… - Cochrane Database …, 2013 - cochranelibrary.com
Background Various methods have been used to try to protect kidney function in patients
undergoing surgery. These most often include pharmacological interventions such as …

Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial

R Tepaske, H Te Velthuis, HM Oudemans-van Straaten… - The Lancet, 2001 - thelancet.com
Background Elderly patients and those with poor ventricular function have increased
morbidity and mortality rates when undergoing surgery. We aimed to ascertain whether an …