Molecular mechanisms of thymoquinone as anticancer agent

F Alhmied, A Alammar, B Alsultan… - … Chemistry & High …, 2021 - ingentaconnect.com
Thymoquinone (TQ), the bioactive constituent of Nigella Sativa seeds, is a well-known
natural compound for the management of several types of cancers. The anti-cancer …

[HTML][HTML] Regulation of nitric oxide production in hypothyroidism

ZM Gluvic, MM Obradovic… - Biomedicine & …, 2020 - Elsevier
Hypothyroidism is a common endocrine disorder that predominantly occurs in females. It is
associated with an increased risk of cardiovascular diseases (CVD), but the molecular …

[HTML][HTML] Celastrol and thymoquinone alleviate aluminum chloride-induced neurotoxicity: Behavioral psychomotor performance, neurotransmitter level, oxidative …

F Abbas, MA Eladl, M El-Sherbiny, N Abozied… - Biomedicine & …, 2022 - Elsevier
Exposure to aluminum chloride (AlCl 3) induces progressive multiregional
neurodegeneration in animal models by promoting oxidative stress and neuroinflammation …

[HTML][HTML] Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats

H Alkis, E Demir, MR Taysi, S Sagir, S Taysi - Biomedicine & …, 2021 - Elsevier
Ionizing radiation leads to release of free radicals into the systemic circulation from
irradiated tissues. These free radicals cause oxidative stress in distant organs. Oxidative …

Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation

H Salmani, M Hosseini, Y Baghcheghi… - Cytokine, 2020 - Elsevier
In recent years, the role of angiotensin II (Ang II) and Ang II type 1 receptor (AT1) in the
crosstalk between the immune system and the central nervous system has received more …

Europinidin Inhibits rotenone-activated parkinson's disease in rodents by decreasing lipid peroxidation and inflammatory cytokines pathways

A Altharawi, KM Alharthy, HN Althurwi, FF Albaqami… - Molecules, 2022 - mdpi.com
Background: Europinidin is a derivative of delphinidin obtained from the plants Plumbago
Europea and Ceratostigma plumbaginoides. This herb has wide medicinal applications in …

Omega-3 fatty acids prevent nicotine withdrawal-induced impairment of learning and memory via affecting oxidative status, inflammatory response, cholinergic activity …

SM Ahmadi-Soleimani, GY Amiry, E Khordad… - Life Sciences, 2023 - Elsevier
In the present study, the main objective was to reveal whether treatment by Omega-3 fatty
acids could prevent the adverse effects of adolescent nicotine withdrawal on spatial and …

Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and …

H Bakhtiari-Dovvombaygi, S Izadi… - Naunyn-Schmiedeberg's …, 2021 - Springer
The objective of this study was to investigate the protective effects of vitamin D (Vit D) on
anxiety and depression-like behaviors induced by unpredictable chronic mild stress and …

Neuroprotective effects of exercise in rodent models of memory deficit and Alzheimer's

Z Jahangiri, Z Gholamnezhad, M Hosseini - Metabolic Brain Disease, 2019 - Springer
Alzheimer's disease (AD) is a fastest growing neurodegenerative condition with no standard
treatment. There are growing evidence about the beneficial effects of exercise in brain …

Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus …

E Kaymak, AT Akin, E Öztürk… - … of Biochemical and …, 2021 - Wiley Online Library
Although doxorubicin (DOX) is used in many cancer treatments, it causes neurotoxicity. In
this study, the effect of thymoquinone (THQ), a powerful antioxidant, on DOX‐induced …