Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …

Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …

Background Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms
have been observed to show a steeper rate of cortical gray matter reduction compared with …

Context Antipsychotic treatment is the first-line treatment option for schizophrenia. Individual
studies suggested they can significantly affect brain structure and account for progressive …

Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …

Progressive grey matter loss has been demonstrated among clinical high-risk (CHR)
individuals who convert to psychosis, but it is unknown whether these changes occur prior to …

It is evident that once psychosis is present in patients with schizophrenia, the underlying
biological process of the illness has already been ongoing for many years. At the time of …

Importance Cannabidiol (CBD) has antipsychotic effects in humans, but how these are
mediated in the brain remains unclear. Objective To investigate the neurocognitive …

Importance Dysregulation of corticostriatal circuitry has long been thought to be critical in the
etiology of psychotic disorders, although the differential roles played by dorsal and ventral …