Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections

HF Hetta, YN Ramadan, IMS Al-Kadmy, NHA Ellah… - Pathogens, 2023 - mdpi.com
An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential
to spread quickly among hospitalized patients and immunodeficient patients causing …

Connecting Cryptococcal Meningitis and Gut Microbiome

Y Ma, L Yang, M Jiang, X Zhao, P Xue - International Journal of Molecular …, 2023 - mdpi.com
Fungal pathogens of the Cryptococcus neoformans species complex (C. neoformans SC)
are a major cause of fungal meningitis in immunocompromised individuals. As with other …

Intelligent diagnostic system for Cryptococcus: Switch-controllable nanocatcher and CNN-based artificial intelligence

F Gu, S Hu, B Tian, T Ma, Y Xu, Y Yang, B Gu - Chemical Engineering …, 2023 - Elsevier
Each year, one million Cryptococcal infections occur among people living with HIV/AIDS,
resulting in nearly 625,000 fatalities due to low efficiency of clinical diagnostic procedures …

Cryptococcal meningitis in apparently immunocompetent patients

J Qu, X Lv - Critical Reviews in Microbiology, 2024 - Taylor & Francis
Cryptococcal meningitis (CM) is an invasive fungal disease that currently poses a threat to
human health worldwide, with high morbidity and mortality, particularly in …

Modeling and Simulation as a Tool to Assess Voriconazole Exposure in the Central Nervous System

KJ Staudt, BB Dias, IA Alves, B Lelièvre, JP Bouchara… - Pharmaceutics, 2023 - mdpi.com
Voriconazole is a triazole antifungal used empirically for the treatment of complicated
meningitis associated with Cryptococcus neoformans. Biopsy studies show that the drug …

Elevated intracranial pressure in cryptococcal meningoencephalitis: examining old, new, and promising drug therapies

AH Alanazi, MS Adil, X Lin, DB Chastain… - Pathogens, 2022 - mdpi.com
Despite the availability of effective antifungal therapy, cryptococcal meningoencephalitis
(CM) remains associated with elevated mortality. The spectrum of symptoms associated with …

Clinical characteristics and risk factors for mortality in cryptococcal meningitis: evidence from a cohort study

F Wang, Y Wang, J He, Z Cheng, S Wu… - Frontiers in …, 2022 - frontiersin.org
Introduction Despite advances in the diagnosis and management, cryptococcal meningitis
(CM) is still associated with high mortality due to insufficient knowledge about clinical …

[HTML][HTML] An uncommon presentation of cryptococcal meningitis in an immunocompetent patient: a case report

K Correa, S Craver, A Sandhu - Clinical Practice and Cases in …, 2021 - ncbi.nlm.nih.gov
Conclusion This case highlights the challenge of identifying cryptococcal meningitis in the
ED, particularly in immunocompetent patients who do not display classic meningitis …

Clinical treatment of cryptococcal meningitis: an evidence-based review on the emerging clinical data

MZ Liu, XH Dai, MT Zeng, EQ Chen - Journal of Neurology, 2024 - Springer
Cryptococcal meningitis (CM) is a fatal fungal central nervous system (CNS) infection
caused by Cryptococcus infecting the meninges and/or brain parenchyma, with fever …

A multi-arm, parallel, preclinical study investigating the potential benefits of acetazolamide, candesartan, and triciribine in combination with fluconazole for the …

AH Alanazi, DB Chastain, M Rudraraju… - European Journal of …, 2023 - Elsevier
Cryptococcus neoformans, an opportunistic fungal pathogen, primarily infects
immunodeficient patients frequently causing cryptococcal meningoencephalitis (CM) …