Introduction: Drug release and oral absorption of drugs with pH-dependent solubility are
influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption …

Published reports have clearly shown that weakly basic drugs which have low solubility at
high pH could have impaired absorption in patients with high gastric pH thus leading to …

Many drug candidates are poorly water-soluble. Microenvironmental pH (pHM) modification
in buccal/sublingual dosage forms has attracted increasing interest as a promising …

Abstract Formulation development of poorly water-soluble compounds can be challenging
because of incomplete dissolution that causes low and variable bioavailability. Enhancing …

Abstract In 2010, the Developability Classification System was proposed as an extension of
the Biopharmaceutics Classification System to align the classification system with the need …

The aim of the present work was to design a pH-modified solid dispersion (pH M-SD) that
can improve the dissolution and bioavailability of poorly water-soluble weakly basic …

Instantly dissolving buccal films have gained attention owing to their easy administration and
capability to surmount the hepatic first pass effect of drugs. Dapoxetine hydrochloride (DPX) …

Purpose To propose media for simulating the intragastric environment under reduced gastric
acid secretion in the fasted state at three levels of simulation of the gastric environment and …

The objective of the present study is to develop sustained release of dipyridamole, a poorly
soluble weakly basic compound. The solubility of dipyridamole is the limit step of its …

The aim of this study was to develop a pH-independent release formulation of dipyridamole
(DP) by the combined use of pH-modifier technology and solid dispersion (SD) technology …