Signal transduction inhibitors

H Rönnberg - Therapeutic Strategies in Veterinary Oncology, 2023 - cabidigitallibrary.org
5 Antimetastatic Therapy Page 1 5 Antimetastatic Therapy NICOLE S. AMATO* Ethos
Veterinary Health, Woburn, Massachusetts, USA Introduction The ability of cancer cells to …

Tumor cell dormancy: Molecular mechanisms, and pharmacological approaches to target dormant cells for countering tumor

MU Saeed, N Hussain, I Zulfiqar, A Raza… - Journal of Drug Delivery …, 2022 - Elsevier
Advancements in oncology have resulted in significant improvement in clinical outputs for
cancer patients. However, Cancer recurrence after initial therapeutic response remains a …

Assessing a novel 3D assay system for drug screening against OS metastasis

N Koons, N Amato, S Sauer, D Warshawsky, D Barkan… - Pharmaceuticals, 2021 - mdpi.com
Osteosarcoma (OS) is an aggressive mesenchymal cell tumor that carries a poor long-term
prognosis. Despite definitive surgery for the primary tumor and adjuvant chemotherapy …

Carbon Nanomaterials: Emerging Roles in Immuno-Oncology

B Patrick, T Akhtar, R Kousar, CC Huang… - International Journal of …, 2023 - mdpi.com
Cancer immunotherapy has made breakthrough progress in cancer treatment. However,
only a subset of patients benefits from immunotherapy. Given their unique structure …

[HTML][HTML] Splicing inhibition mediated by reduced splicing factors and helicases is associated with the cellular response of lung cancer cells to cisplatin

L Wang, N Yin, W Shi, Y Xie, J Yi, Z Tang, J Tang… - Computational and …, 2024 - Elsevier
Lung cancer's mortality is predominantly linked to post-chemotherapy recurrence, driven by
the reactivation of dormant cancer cells. Despite the critical role of these reactivated cells in …

Dual FGFR-targeting and pH-activable Ruthenium-Peptide Conjugates for targeted therapy of Breast Cancer

JF Machado, M Sá, I Pires, MT da Silva… - Dalton …, 2024 - pubs.rsc.org
Dysregulation of Fibroblast Growth Factor Receptors (FGFRs) signaling has been
associated with breast cancer, yet employing FGFR-targeted delivery systems to improve the …

[HTML][HTML] Mini-Review: Can the Metastatic Cascade Be Inhibited by Targeting CD147/EMMPRIN to Prevent Tumor Recurrence?

MA Rahat - Frontiers in Immunology, 2022 - frontiersin.org
Solid tumors metastasize very early in their development, and once the metastatic cell is
lodged in a remote organ, it can proliferate to generate a metastatic lesion or remain …

Immunophenotype rearrangement in response to tumor excision may be related to the risk of biochemical recurrence in prostate cancer patients

P Bosas, G Zaleskis, D Dabkevičiene… - Journal of Clinical …, 2021 - mdpi.com
Background: Prostate cancer (PCa) is known to exhibit a wide spectrum of aggressiveness
and relatively high immunogenicity. The aim of this study was to examine the effect of tumor …

The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and …

E Smorodin, V Chuzmarov, T Veidebaum - Current Oncology, 2024 - mdpi.com
Melatonin is a multifunctional hormone regulator that maintains homeostasis through
circadian rhythms, and desynchronization of these rhythms can lead to gastrointestinal …

具有休眠特征的播散肿瘤细胞体内外研究模型的建立及应用

阙祖俊, 刘佳君, 田建辉 - 肿瘤防治研究, 2023 - zlfzyj.com
摘要术后无症状的早期癌症(肺癌) 患者的转移靶器官中已经潜伏有处于休眠状态的播散肿瘤
细胞(DTCs), 其增殖是导致临床转移发生的关键环节. 开发维持DTCs 休眠或根除休眠DTCs …