mRNA, a revolution in biomedicine
The perspective of using messenger RNA (mRNA) as a therapeutic molecule first faced
some uncertainties due to concerns about its instability and the feasibility of large-scale …
some uncertainties due to concerns about its instability and the feasibility of large-scale …
Microfluidic transfection of mRNA into human primary lymphocytes and hematopoietic stem and progenitor cells using ultra-fast physical deformations
J Loo, I Sicher, A Goff, O Kim, N Clary, A Alexeev… - Scientific Reports, 2021 - nature.com
Messenger RNA (mRNA) delivery provides gene therapy with the potential to achieve
transient therapeutic efficacy without risk of insertional mutagenesis. Amongst other …
transient therapeutic efficacy without risk of insertional mutagenesis. Amongst other …
Lipid based drug delivery systems for oral, transdermal and parenteral delivery: recent strategies for targeted delivery consistent with different clinical application
AK Srivastav, S Karpathak, MK Rai, D Kumar… - Journal of Drug Delivery …, 2023 - Elsevier
Lipid based drug delivery systems (LBDDS) are valuable and biocompatible nano-carriers
for the vehiculation and potential delivery of various hydrophilic, hydrophobic, or amphiphilic …
for the vehiculation and potential delivery of various hydrophilic, hydrophobic, or amphiphilic …
[HTML][HTML] Clinical progress of nanomedicine-based RNA therapies
The clinical application of nanoparticles (NPs) to deliver RNA for therapy has progressed
rapidly since the FDA approval of Onpattro® in 2018 for the treatment of polyneuropathy …
rapidly since the FDA approval of Onpattro® in 2018 for the treatment of polyneuropathy …
[HTML][HTML] Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for …
Lipid-based nanoparticles for RNA delivery (LNP-RNA) are revolutionizing the
nanomedicine field, with one approved gene therapy formulation and two approved …
nanomedicine field, with one approved gene therapy formulation and two approved …
Engineered mRNA delivery systems for biomedical applications
J Wang, H Zhu, J Gan, G Liang, L Li… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA)‐based therapeutic strategies have shown remarkable promise in
preventing and treating a staggering range of diseases. Optimizing the structure and …
preventing and treating a staggering range of diseases. Optimizing the structure and …
[HTML][HTML] mRNA delivery in cancer immunotherapy
Messenger RNA (mRNA) has drawn much attention in the medical field. Through various
treatment approaches including protein replacement therapies, gene editing, and cell …
treatment approaches including protein replacement therapies, gene editing, and cell …
Toward gene transfer nanoparticles as therapeutics
EW Kavanagh, JJ Green - Advanced Healthcare Materials, 2022 - Wiley Online Library
Genetic medicine has great potential to treat the underlying causes of many human
diseases with exquisite precision, but the field has historically been stymied by delivery as …
diseases with exquisite precision, but the field has historically been stymied by delivery as …
Nonviral delivery systems of mRNA vaccines for cancer gene therapy
Y Wang, R Zhang, L Tang, L Yang - Pharmaceutics, 2022 - mdpi.com
In recent years, the use of messenger RNA (mRNA) in the fields of gene therapy,
immunotherapy, and stem cell biomedicine has received extensive attention. With the …
immunotherapy, and stem cell biomedicine has received extensive attention. With the …
Delivery of synthetic mRNAs for tissue regeneration
H Steinle, J Weber, S Stoppelkamp… - Advanced drug delivery …, 2021 - Elsevier
In recent years, nucleic acid-based therapeutics have gained increasing importance as
novel treatment options for disease prevention and treatment. Synthetic messenger RNAs …
novel treatment options for disease prevention and treatment. Synthetic messenger RNAs …