Meta-inflammation and metabolic reprogramming of macrophages in diabetes and obesity: the importance of metabolites

S Russo, M Kwiatkowski, N Govorukhina… - Frontiers in …, 2021 - frontiersin.org
Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …

[HTML][HTML] Mitochondrial sirtuins, metabolism, and aging

Z Ji, GH Liu, J Qu - Journal of Genetics and Genomics, 2022 - Elsevier
Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

[HTML][HTML] Mitochondrial alterations in fatty liver diseases

B Fromenty, M Roden - Journal of hepatology, 2023 - Elsevier
Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic
exposure and excessive alcohol use, all of which have been shown to exert toxic effects on …

[HTML][HTML] Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

V Kumar, S Kundu, A Singh, S Singh - Current neuropharmacology, 2022 - ncbi.nlm.nih.gov
Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

MR Chaudhary, S Chaudhary, Y Sharma, TA Singh… - Biogerontology, 2023 - Springer
Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

The role of SIRT3 in exercise and aging

L Zhou, R Pinho, Y Gu, Z Radak - Cells, 2022 - mdpi.com
The health benefits of regular exercise are well established. Nonetheless, the molecular
mechanism (s) responsible for exercise-induced health benefits remain a topic of debate …

Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …

The mitochondrial unfolded protein response: A multitasking giant in the fight against human diseases

Z Zhou, Y Fan, R Zong, K Tan - Ageing Research Reviews, 2022 - Elsevier
Mitochondria, which serve as the energy factories of cells, are involved in cell differentiation,
calcium homeostasis, amino acid and fatty acid metabolism and apoptosis. In response to …

[HTML][HTML] A comprehensive overview of the complex role of oxidative stress in aging, the contributing environmental stressors and emerging antioxidant therapeutic …

E Iakovou, M Kourti - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Introduction: Aging is a normal, inevitable, irreversible and progressive process which is
driven by internal and external factors. Oxidative stress, that is the imbalance between …

Astaxanthin as a novel mitochondrial regulator: a new aspect of carotenoids, beyond antioxidants

Y Nishida, A Nawaz, K Hecht, K Tobe - Nutrients, 2021 - mdpi.com
Astaxanthin is a member of the carotenoid family that is found abundantly in marine
organisms, and has been gaining attention in recent years due to its varied biological …