Liposomes have a wide array of uses that have been continuously expanded and improved
upon since first being observed to self‐assemble into vesicular structures. These …

Polymeric carriers have emerged as major non-viral alternatives for gene delivery due to
their lower immunogenicity and pathogenicity. However, during intracellular delivery of …

One of the unmet challenges in nanotechnology is to understand and establish the
relationship between physicochemical properties of nanoparticles (NPs) and its biological …

Cancer vaccines based on mRNA are extensively studied. The fragile nature of mRNA has
instigated research into carriers that can protect it from ribonucleases and as such enable its …

Today, liposomes are an advanced technology of drug carriers with a dozen drugs in clinical
practice and many more in clinical trials. A bottleneck associated with the clinical translation …

The effects of lipid compositions on their physicochemical properties and transfection
efficiencies were investigated. Four liposome formulations with different 1, 2-dioleoyl-3 …

Serum has often been reported as a barrier to efficient lipid-mediated transfection. Here we
found that the transfection efficiency of DC-Chol–DOPE/DNA lipoplexes increases in serum …

Gene-based therapeutic approaches are based upon the concept that, if a disease is
caused by a mutation in a gene, then adding back the wild-type gene should restore regular …

A decade has passed since the concept of the protein corona, as originally termed by
Dawson and coworkers in 2007, was extended to liposomes. Although the protein binding to …

Lipid nanoparticles (LNPs) have been widely investigated for nucleic acid therapeutic
delivery, and demonstrated their potential in enabling new mRNA vaccines. LNPs are …