Undoubtedly, the discovery of penicillin is one of the greatest milestones in modern
medicine. 2016 marks the 75th anniversary of the first systemic administration of penicillin in …

Background The effect of procalcitonin-guided use of antibiotics on treatment for suspected
lower respiratory tract infection is unclear. Methods In 14 US hospitals with high adherence …

Summary The Core Elements of Outpatient Antibiotic Stewardship provides a framework for
antibiotic stewardship for outpatient clinicians and facilities that routinely provide antibiotic …

Background Optimum management of childhood diarrhoea in low-resource settings has
been hampered by insufficient data on aetiology, burden, and associated clinical …

Importance The benefits of antimicrobial prophylaxis are limited to the first 24 hours
postoperatively. Little is known about the harms associated with continuing antimicrobial …

Background The objective of our study was to describe trends in US outpatient antibiotic
prescriptions from January through May 2020 and compare with trends in previous years …

Importance The large overlap between symptoms of acute sinusitis and viral upper
respiratory tract infection suggests that certain subgroups of children being diagnosed with …

Importance Assessing the scope of acute medication harms to patients should include both
therapeutic and nontherapeutic medication use. Objective To describe the characteristics of …

Antibiotic resistance is one of the greatest worldwide challenges to modern medicine, and
society at large, and one of the least appreciated by practitioners and the lay community …

Background Inappropriate antibiotic use greatly accelerates antimicrobial resistance. The
appropriateness of antibiotic prescriptions is well evaluated, using big observational data, in …