Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …

Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the
same peptide or protein has emerged in the past two decades as a major pathway for both …

Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary human and financial burdens. Studies of …

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …

Transient soluble oligomers of amyloid-β (Aβ) are toxic and accumulate early prior to
insoluble plaque formation and cognitive impairment in Alzheimer's disease (AD). Synthetic …

Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

In vitro, β-amyloid (Aβ) peptides form polymorphic fibrils, with molecular structures that
depend on growth conditions, plus various oligomeric and protofibrillar aggregates. Here …

Compartmentalization by liquid-liquid phase separation (LLPS) has emerged as a
ubiquitous mechanism underlying the organization of biomolecules in space and time. Here …

Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from
bench to clinic. Current probes and drugs attempting to prevent β‐amyloid (Aβ) fibrosis …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …