Publisher Summary The chapter describes the understanding of the physics and physical
chemistry of sickle cell hemoglobin polymerization in solutions and in red cells. The …

A double nucleation mechanism for the polymerization of sickle hemoglobin is described.
The mechanism accounts for all of the major kinetic observations: the appearance of a …

We examined the extent to which the intracellular polymerization of sickle hemoglobin (HbS)
can account for the severity of anemia and of vaso-occlusive manifestations in the various …

The kinetics of deoxyhemoglobin S gelation have been investigated using photolytic
dissociation of the carbon monoxide complex to initiate the process. Measurements over a …

A laser photolysis technique has been developed to assess the quantitative significance of
the delay time of hemoglobin S gelation to the pathophysiology of sickle cell disease …

In the last few years, the understanding of the molecular basis of sickle cell disease has
progressed rapidly. It is now possible to describe the structure of the gel of polymerized …

THE term" molecular disease" was coined almost 30 years ago by Linus Pauling and his
associates to describe their analysis of the abnormality in sickle-cell anemia. 1 Since that …

Abstract Preface; 1. Introduction; 2. Globular protein structure; 3. Experimental methods; 4.
Thermodynamics and statistical mechanics; 5. Protein-protein interactions; 6. Theoretical …

Publisher Summary This chapter is concerned with polarized absorption and linear
dichroism spectroscopy of hemoglobin. Polarized absorption and linear dichroism are …

Abstract 70 years ago, Linus Pauling, the legendary genius of 20th century chemistry,
published his famous work on the molecular cause of sickle cell disease, a paper that gave …