The polymerization kinetics of sickle cell hemoglobin are found to exhibit stochastic
variations when observed in very small volumes (~ 10− 10 cm 3). The distribution of …

The thermodynamics of sickle cell hemoglobin gelation in the presence of oxygen has been
investigated by measuring the fractional saturation of the solution and polymer phases, and …

Recent interest in therapies for sickle cell anemia based on elevating fetal Hb has made
accurate estimates of the sparing effect of fetal Hb (Hb F) and other non-sickle Hbs on sickle …

We report the results of thermodynamic and kinetic studies on the gelation of mixtures of
sickle cell (S) deoxyhemoglobin with normal human adult (A) and fetal (F) …

Abstract We have established that 2, 3-diphosphoglycerate (2, 3-DPG) content and
intracellular pH exert separate, but interdependent, effects on the equilibrium solubility (csat) …

The primary pathophysiological event in the erythrocytes of individuals with the various
sickle syndromes is the intracellular aggregation or polymerization of sickle haemoglobin …

Thiol reagents react with cysteine beta 93 of hemoglobin and as a result increase the
oxygen affinity of hemoglobin. In the present studies we have used a thiol-disulfide …

We have used 13C/1H magnetic double-resonance spectroscopy to measure the amount of
sickle hemoglobin polymer within sickle erythrocytes as a function of oxygen saturation. We …

To determine the extent to which the broad distribution in intracellular hemoglobin
concentrations found in sickle erythrocytes affects the extent of intracellular polymerization of …