This chapter surveys the molecular events that cause individual hemoglobin tetramers to
become a stiff polymer mass with devastating consequences. It outlines the principles of …

Les vésicules sont des bicouches lipidiques refermées sur elles même, séparant ainsi un
volume intérieur du milieu extérieur. Elles sont donc utilisées dans de nombreuses …

This paper presents data on the effect of phosphates and polyphosphates on the formation
of hemoglobin S fiber, and on the Bohr effect of hemoglobin S samples whose concentration …

TWO abnormal high oxygen affinity haemoglobins have been studied for their ability to
inhibit the polymerization of deoxy‐Hb S. They were used as models to predict the effect of …

Sickle cell anemia (SCA) afflicts Afro-Americans in the United-States, and black people in
most South-American, African, and West-Indies countries. In sickle cell disease, sickler …

Polymerization of half-liganded Hb S was investigated using Ni (II) Fe (II) hybrid Hb S, in
which heme in either α or β s subunits is replaced by Ni (II) protoporphyrin IX. Studies on the …

This thesis is concerned with exploiting our knowledge of the thermodynamics and kinetics
of sickle cell hemoglobin polymerization to provide a quantitative rationale for developing …

The predominant structure in gels and crystals of deoxy Hb S “and in sickled erythrocytes is
a half-staggered pair of strands of Hb tetramers. Similar half-staggered double strands of …

The addition of normal deoxyhemoglobin (Hb" A)” and of two forms of sickle hemo-globin
(COHb and Hb") to solution of sickle deoxyhemoglobin (Hb" S) reduces the solubility of the …

My colleagues, Dr. Weijun Weng, Dr. Mikhail Zakharov, Dr. Zenghui Liu, and Dr. Yihua
Wang have been a great resource as well; from helping me in the lab to engaging in long …