The process of aging refers to physiological changes that occur to an organism as time
progresses and involves changes to DNA, proteins, metabolism, cells, and organs. Like the …

As a link between a stable genome and a dynamic environment, epigenetics is a promising
tool for mapping age-related changes in human DNA. Methylated cytosine changes at …

The sperm epigenome is thought to affect the developmental programming of the resulting
embryo, influencing health and disease in later life. Age‐related methylation changes in the …

Children from old fathers carry an increased risk for autism spectrum (ASD) and other
neurodevelopmental disorders, which may at least partially be mediated by paternal age …

In brief In light of the increasing age of first-time fathers, this article summarizes the current
scientific knowledge base on reproductive aging in the male, including sperm quality and …

Exposure to air pollutants has been associated with adverse health outcomes in adults and
children who were prenatally exposed. In addition to reducing exposure to air pollutants, it is …

As global demographics shift toward increasing paternal age, the realm of assisted
reproductive technologies (ARTs), particularly in vitro fertilization (IVF) and intracytoplasmic …

In modern times, a notable trend toward delayed childbearing has been observed in most
developed countries. As a result, sperm aging and quality loss, as well as premature ovarian …

Background Genetic syndromes of hyperkinetic movement disorders associated with
epileptic encephalopathy and intellectual disability are becoming increasingly recognized …

Male infertility has been a primary cause of global infertility, affecting 8–12% of couples
worldwide. Previous studies have shown that semen quality decreases with advanced aging …