Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius
var. Caesius and belongs to the anthracyclines family. The anti-cancer activity of Dox is …

Doxorubicin is an effective chemotherapeutic agent prescribed to treat solid tumors (eg,
ovary, breast, and gastrointestinal cancers). This anti-cancer drug has various side effects …

As a potent chemotherapeutic agent, doxorubicin (DOX) is widely used for the treatment of a
variety of cancers However, its clinical utility is limited by dose-dependent cardiotoxicity, and …

A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment.
Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle …

Pterostilbene is a demethylated resveratrol derivative with attractive anti-inflammatory, anti-
tumor and anti-oxidative stress activities. However, the clinical use of pterostilbene is limited …

Diabetes is associated with an increased risk of heart failure (HF). This is commonly termed
diabetic cardiomyopathy and is often characterised by increased cardiac fibrosis …

The balance between pro-and antioxidant molecules has been established as an important
driving force in the pathogenesis of cardiovascular disease. Chronic heart failure is …

Protein acetylation has emerged to play pivotal roles in alcoholic liver disease (ALD). Sirutin
2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase involved …

Liver fibrosis is an important pathologic process in response to chronic or repetitive liver
injury. It can advance to liver cirrhosis. Both peroxisome proliferator-activated receptor …