RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …

Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Simple Summary RNA-binding proteins (RBPs) play central roles in regulating
posttranscriptional expression of genes. Many of them are known to be deregulated in a …

The exocyst is an octameric protein complex that is implicated in the tethering of secretory
vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal …

Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …

Alternative splicing provides a major mechanism to generate protein diversity. Increasing
evidence suggests a link of dysregulation of splicing associated with cancer. Genome-wide …

Alternative splicing has been shown to causally contribute to the epithelial–mesenchymal
transition (EMT) and tumor metastasis. However, the scope of splicing factors that govern …

ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 regulate alternative splicing
events associated with epithelial phenotypes of cells, and both are down-regulated during …

Regulation of vascular permeability, recruitment of leukocytes from blood to tissue and
angiogenesis are all processes that occur at the level of the microvasculature during both …