Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

Cellular senescence is a recognized mechanism of tumour suppression; however, its
contribution to other pathologies is not well understood. We show that the matricellular …

Abstract N 6-Methyladenosine (m 6 A) is the most prevalent internal modification in
mammalian mRNAs. Although m 6 A is important in many biological processes, its roles in …

The extracellular matrix (ECM) is a complex network of proteins, glycoproteins,
proteoglycans, and polysaccharides. Through multiple interactions with each other and the …

In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Abstract CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein
that plays essential roles in cardiovascular development during embryogenesis, and …

The placenta is essential for sustaining the growth of the fetus during gestation, and defects
in its function result in fetal growth restriction or, if more severe, fetal death. Several …

Coordinated production and remodeling of the extracellular matrix is essential during
development. It is of particular importance for skeletogenesis, as the ability of cartilage and …

Members of the CCN (CYR61/CTGF/NOV) family have emerged as dynamically expressed,
extracellular matrix-associated proteins that play critical roles in cardiovascular and skeletal …