NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …

Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

Acetaminophen (APAP)-induced liver injury (AILI) has become a growing public health
problem. Ferroptosis, an iron-dependent form of cell death associated with lipid peroxide …

Inflammatory bowel disease (IBD) represents chronic recurrent intestinal inflammation
resulting from various factors. Crohn's disease (CD) and ulcerative colitis (UC) have been …

Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription
factor, has been documented to induce a defense mechanism against oxidative stress …

Despite advancements in synthetic chemistry, nature remains the primary source of drug
discovery, and this never-ending task of finding novel and active drug molecules will …

Cisplatin is a chemotherapy drug that is often used in clinical practice, but its frequent use
often leads to nephrotoxicity. Therefore, we urgently need a drug that reduces the …

Objective Acetaminophen (APAP) is one of the world's popular and safe painkillers, and
overdose can cause severe liver damage and even acute liver failure. The effect and …

Nephropathy can occur following exposure of the kidneys to oxidative stress. Oxidative
stress is the result of reactive oxygen species (ROS) formation due to intracellular …

Oxidative stress‐mediated endothelial injury is considered to be involved in the
pathogenesis of various cardiovascular diseases. Farrerol, a typical natural flavanone from …