Could aging evolve as a pathogen control strategy?

PV Lidsky, R Andino - Trends in Ecology & Evolution, 2022 - cell.com
Aging is often attributed to the detrimental side effects of beneficial traits but not a
programmed adaptive process. Alternatively, the pathogen control hypothesis posits that …

Mitochondrion-targeted antioxidant SkQ1 prevents rapid animal death caused by highly diverse shocks

VP Skulachev, MY Vyssokikh, BV Chernyak… - Scientific Reports, 2023 - nature.com
The response to stress involves the activation of pathways leading either to protection from
the stress origin, eventually resulting in development of stress resistance, or activation of the …

Innate immunity as an executor of the programmed death of individual organisms for the benefit of the entire population

BV Chernyak, KG Lyamzaev… - International Journal of …, 2021 - mdpi.com
In humans, over-activation of innate immunity in response to viral or bacterial infections often
causes severe illness and death. Furthermore, similar mechanisms related to innate …

Anti-cancer virotherapy in Russia: lessons from the past, current challenges and prospects for the future

NM Kolyasnikova, NB Pestov… - Current …, 2023 - ingentaconnect.com
The idea of using the lytic power of viruses against malignant cells has been entertained for
many decades. However, oncolytic viruses gained broad attention as an emerging anti …

Is aging an inevitable characteristic of organic life or an evolutionary adaptation?

PV Lidsky, J Yuan, JM Rulison… - Biochemistry (Moscow …, 2022 - Springer
Aging is an evolutionary paradox. Several hypotheses have been proposed to explain it, but
none fully explains all the biochemical and ecologic data accumulated over decades of …

Altruism and phenoptosis as programs supported by evolution

GA Shilovsky, TS Putyatina, AV Markov - Biochemistry (Moscow), 2021 - Springer
Phenoptosis is a programmed death that has emerged in the process of evolution,
sometimes taking the form of an altruistic program. In particular, it is believed to be a weapon …

[PDF][PDF] Reconsidering life history theory amid infectious diseases

PV Lidsky, J Yuan, R Andino - Trends in Ecology & Evolution, 2023 - researchgate.net
The pathogen control evolutionary hypothesis (PCH) of aging was critically analyzed by
Criscuolo et al.[1]. According to PCH, a shorter lifespan might have evolved to eliminate …

Host age structure reshapes parasite symbiosis: collaboration begets pathogens, competition begets virulent mutualists

COS Portner, EG Rong, JA Ramirez, YI Wolf, AP Bosse… - Biology Direct, 2022 - Springer
Background Symbiotic relationships are ubiquitous in the biosphere. Inter-species symbiosis
is impacted by intra-specific distinctions, in particular, those defined by the age structure of a …

Host Age Structure Defines Interactions with Pathogens: Grandparent Effect under Collaboration and Virulent Mutualism under Competition

COS Portner, EG Rong, JA Ramirez, YI Wolf, AP Bosse… - bioRxiv, 2022 - biorxiv.org
Background Symbiotic relationships are ubiquitous in the biosphere. Inter-species symbiosis
is impacted by intra-specific distinctions, in particular, those defined by the age structure of a …

Oncolytic Viruses in Tumor Therapy: The Russian Perspective

NM Kolyasnikova, NB Pestov, JM Sanchez-Pimentel… - 2021 - preprints.org
The idea of using the lytic power of viruses against the malignant cells has been entertained
for many decades. However, oncolytic viruses (OV) gained broad attention as an emerging …