[HTML][HTML] Levodopa-induced dyskinesia in Parkinson's disease: pathogenesis and emerging treatment strategies

DK Kwon, M Kwatra, J Wang, HS Ko - Cells, 2022 - mdpi.com
The most commonly used treatment for Parkinson's disease (PD) is levodopa, prescribed in
conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement …

Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease

P Saha, H Kathuria, MM Pandey - Journal of Controlled Release, 2023 - Elsevier
Parkinson's disease (PD) is the second leading neurodegenerative disease globally,
impacting the quality of life of millions of people. It is estimated that the treatment cost of PD …

Nose-to-brain delivery of rotigotine redispersible nanosuspension: In vitro and in vivo characterization

P Saha, H Kathuria, MM Pandey - Journal of Drug Delivery Science and …, 2023 - Elsevier
Rotigotine (RTG) is an anti-Parkinson's drug approved by the USFDA to treat motor and non-
motor symptoms of both early and advanced stages of the disease. However, issues like …

Targeting G protein-coupled receptors in the treatment of Parkinson's disease

J Jones-Tabah - Journal of Molecular Biology, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized in part
by the deterioration of dopaminergic neurons which leads to motor impairment. Although …

Snake venom nerve growth factor-inspired designing of novel peptide therapeutics for the prevention of paraquat-induced apoptosis, neurodegeneration, and …

D Madhubala, A Patra, T Islam, K Saikia… - Free Radical Biology …, 2023 - Elsevier
Neurodegenerative disorders (ND), associated with the progressive loss of neurons,
oxidative stress-mediated production of reactive oxygen species (ROS), and mitochondrial …

Self-assembled ruthenium decorated electrochemical platform for sensitive and selective determination of amisulpride in presence of co-administered drugs using …

AM Asran, MA Mohamed, GMG Eldin, RK Mishra… - Microchemical …, 2021 - Elsevier
A wholly new electroanalytical protocol for the sensitive determination of Amisulpride (AMS)
has been developed. AMS is an antipsychotic and antiemetic medicine that is prescribed at …

[HTML][HTML] The effect and safety of ropinirole in the treatment of Parkinson disease: a systematic review and meta-analysis

J Zhu, M Chen - Medicine, 2021 - journals.lww.com
Background: It is necessary to conduct a meta-analysis of the clinical randomized controlled
trials (RCTs) on ropinirole in the treatment of Parkinson disease (PD), to explore the effects …

[HTML][HTML] Identification of potential Parkinson's disease drugs based on multi-source data fusion and convolutional neural network

J Liu, D Peng, J Li, Z Dai, X Zou, Z Li - Molecules, 2022 - mdpi.com
Parkinson's disease (PD) is a serious neurodegenerative disease. Most of the current
treatment can only alleviate symptoms, but not stop the progress of the disease. Therefore, it …

Prevalence and correlates of psychiatric comorbidity and multimorbidity in Parkinson's disease and atypical parkinsonian syndromes

V Patel, J Ts, N Kamble, R Yadav, TK… - Journal of Geriatric …, 2023 - journals.sagepub.com
Purpose Psychiatric comorbidity in Parkinson's disease (PD) and atypical parkinsonian
syndromes (APS) has been consistently associated with poor outcomes. However, the co …

Future Directions for Developing Non-dopaminergic Strategies for the Treatment of Parkinson's Disease

DJ Wamelen, V Leta, K Chaudhuri… - Current …, 2024 - ingentaconnect.com
The symptomatic treatment of Parkinson's disease (PD) has been dominated by the use of
dopaminergic medication, but significant unmet need remains, much of which is related to …