Zinc fingers (ZFs) are among the most structurally diverse protein domains. They interact
with nucleic acids, other proteins and lipids to facilitate a multitude of biological processes …

Metal ions are essential elements present in biological systems able to facilitate many
cellular processes including proliferation, signaling, DNA synthesis and repair. Zinc ion (Zn …

Oxidative stress is a state involving an imbalance of reactive oxygen species in a cell and is
linked to a variety of diseases. The metal-binding protein metallothionein (MT) may play a …

Abstract A new ligand 2-[2′-(5-Nitrothiazolyl) azo]-4-methoxyphenol (NTAMP) was
synthesized using the coupling reaction between 2-amino-5-nitrothiazole and 4 …

Metal ions play many critical roles in biology, as structural and catalytic cofactors, and as cell
regulatory and signalling elements. The metal–protein affinity, expressed conveniently by …

Mammalian metallothioneins (MTs) are small cysteine-rich proteins whose primary role is
participation in zinc and copper homeostasis. Ever since their discovery, MTs have been …

The progression of neurodegenerative disorders can lead to impaired neurotransmission;
however, the role of pathogenic factors associated with these diseases and their impact on …

Zinc fingers (ZFs) are among the most abundant motifs found in proteins, and are commonly
known for their structural role. Classical ZFs (CCHH) are part of the transcription factors that …

A significant aspect of the control of cellular zinc in eukarya is its subcellular re‐distribution.
One of the four human vesicular zinc transporters, ZnT8, supplies the millimolar zinc …

In protein design, the energy associated with a huge number of sequence-conformer
perturbations has to be routinely estimated. Hence, enhancing the throughput and accuracy …