Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Thyroid hormone is a critical regulator of growth, development and metabolism in virtually all
tissues, and altered thyroid status affects many organs and systems. Although for many …

The predominant testicular gap junctional protein connexin43 (cx43) is located between
neighboring Sertoli cells (SCs) and between SCs and germ cells. It is assumed to be …

GJA1 (also known and referred to here as connexin 43 and abbreviated CX43) is the
predominant testicular gap junction protein, and CX43 may regulate Sertoli cell maturation …

Sox9 and Sox8 are transcription factors expressed in embryonic and postnatal Sertoli cells
of the mouse testis. Sox9 inactivation prior to the sex determination stage leads to complete …

Background A growing body of evidence has found links between endocrine disruptor
phthalates and male reproductive disorders, but the mechanisms underlying these …

β-Catenin, as an important effector of the canonical Wnt signaling pathway and as a
regulator of cell adhesion, has been demonstrated to be involved in multiple developmental …

The gap junction protein connexin43 (CX43) plays a vital role in mammalian
spermatogenesis by allowing for direct cytoplasmic communication between neighbouring …

The role of gap junctional intercellular communication (GJIC) in regulation of normal growth
and differentiation is becoming increasingly recognized as a major cellular function. GJIC …

The blood–testis barrier (BTB) formed by adjacent Sertoli cells is composed of coexisting
tight junction (TJ), basal ectoplasmic specialization (ES), and desmosome-like junction …