[PDF][PDF] The bidirectional relationship of depression and inflammation: double trouble

E Beurel, M Toups, CB Nemeroff - Neuron, 2020 - cell.com
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways

AS Correia, N Vale - International journal of molecular sciences, 2022 - mdpi.com
Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …

[PDF][PDF] Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells

EC Rosser, CJM Piper, DE Matei, PA Blair… - Cell metabolism, 2020 - cell.com
The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-
microbiota-derived signals supports the maintenance of tolerance. However, whether …

[HTML][HTML] Tryptophan metabolism: a link between the gut microbiota and brain

K Gao, C Mu, A Farzi, W Zhu - Advances in Nutrition, 2020 - Elsevier
The gut-brain axis (GBA) is a bilateral communication network between the gastrointestinal
(GI) tract and the central nervous system. The essential amino acid tryptophan contributes to …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

[HTML][HTML] The brain-gut-microbiome axis

CR Martin, V Osadchiy, A Kalani, EA Mayer - Cellular and molecular …, 2018 - Elsevier
Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-
microbiome axis. Gut microbes communicate to the central nervous system through at least …

The role of inflammation and the gut microbiome in depression and anxiety

JM Peirce, K Alviña - Journal of neuroscience research, 2019 - Wiley Online Library
The study of the gut microbiome has increasingly revealed an important role in modulating
brain function and mental health. In this review, we underscore specific pathways and …

[HTML][HTML] Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism

J Gao, K Xu, H Liu, G Liu, M Bai, C Peng… - Frontiers in cellular and …, 2018 - frontiersin.org
The gut microbiota influences the health of the host, especially with regard to gut immune
homeostasis and the intestinal immune response. In addition to serving as a nutrient …

Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice

SH Lee, SY Cho, Y Yoon, C Park, J Sohn… - Nature …, 2021 - nature.com
The gut microbiome can influence the development of tumours and the efficacy of cancer
therapeutics,,,–; however, the multi-omics characteristics of antitumour bacterial strains have …