Site-Specific Synthesis and Characterization of Oligonucleotides Containing an N6-(2-Deoxy-d-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N …
PP Christov, KL Brown, ID Kozekov… - Chemical research in …, 2008 - ACS Publications
A phosphoramidite reagent of N 6-(2-deoxy-d-erythro-pentofuranosyl)-2, 6-diamino-1, 4-
dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy-dGuo) lesions was synthesized in …
dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy-dGuo) lesions was synthesized in …
OGG1 protein suppresses G: C→ T: A mutation in a shuttle vector containing 8-hydroxyguanine in human cells
N Sunaga, T Kohno, K Shinmura, T Saitoh… - …, 2001 - academic.oup.com
Hydroxyguanine (8-OHG) is an oxidatively damaged mutagenic base which causes G: C→
T: A transversions in DNA. OGG1 was cloned as a human gene encoding a DNA …
T: A transversions in DNA. OGG1 was cloned as a human gene encoding a DNA …
DNA substrates containing defined oxidative base lesions and their application to study substrate specificities of base excision repair enzymes
H Ide - Progress in Nucleic Acid Research and Molecular …, 2001 - Elsevier
Reactive oxygen species generate structurally diverse base lesions in DNA. These lesions
are primarily removed by base excision repair (BER) enzymes in prokaryotic and eukaryotic …
are primarily removed by base excision repair (BER) enzymes in prokaryotic and eukaryotic …
Protection of human lung cells against hyperoxia using the DNA base excision repair genes hOgg1 and Fpg
M Wu, YH He, M Kobune, Y Xu, MR Kelley… - American Journal of …, 2002 - atsjournals.org
Hyperoxia causes pulmonary toxicity in part by injuring alveolar epithelial cells. Previous
studies have shown that toxic oxygen-derived species damage DNA and this damage is …
studies have shown that toxic oxygen-derived species damage DNA and this damage is …
Mammalian 5-Formyluracil− DNA Glycosylase. 1. Identification and Characterization of a Novel Activity That Releases 5-Formyluracil from DNA
M Matsubara, A Masaoka, T Tanaka, T Miyano… - Biochemistry, 2003 - ACS Publications
5-Formyluracil (fU) is a major oxidative thymine lesion produced by reactive oxygen species
and exhibits genotoxic and cytotoxic effects via several mechanisms. In the present study …
and exhibits genotoxic and cytotoxic effects via several mechanisms. In the present study …
Action-at-a-distance mutations at 5′-GpA-3′ sites induced by oxidised guanine in WRN-knockdown cells
T Suzuki, H Masuda, M Mori, R Ito, H Kamiya - Mutagenesis, 2021 - academic.oup.com
G: C sites distant from 8-oxo-7, 8-dihydroguanine (GO, 8-hydroxyguanine) are frequently
mutated when the lesion-bearing plasmid DNA is replicated in human cells with reduced …
mutated when the lesion-bearing plasmid DNA is replicated in human cells with reduced …
Replication of the 2,6-Diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine (MeFapy-dGuo) Adduct by Eukaryotic DNA Polymerases
PP Christov, K Yamanaka, JY Choi… - Chemical research in …, 2012 - ACS Publications
N 6-(2-Deoxy-d-erythro-pentofuranosyl)-2, 6-diamino-3, 4-dihydro-4-oxo-5-N-
methylformamidopyrimidine (MeFapy-dGuo) has been identified as a stable DNA adduct …
methylformamidopyrimidine (MeFapy-dGuo) has been identified as a stable DNA adduct …
Social stress induces oxidative DNA damage in mouse peripheral blood cells
Y Nishio, Y Nakano, Y Deguchi, H Terato… - Genes and …, 2007 - jstage.jst.go.jp
We investigated whether or not social stress (isolation, 1 mouse per cage) increases
oxidative DNA damage in mouse peripheral blood cells. Male BALB/c mice (4 weeks old) …
oxidative DNA damage in mouse peripheral blood cells. Male BALB/c mice (4 weeks old) …
In vitro replication and repair studies of tandem lesions containing neighboring thymidine glycol and 8-oxo-7, 8-dihydro-2′-deoxyguanosine
Reactive oxygen species can induce the formation of tandem DNA lesions. We recently
showed that the treatment of calf thymus DNA with Cu2+/H2O2/ascorbate could result in the …
showed that the treatment of calf thymus DNA with Cu2+/H2O2/ascorbate could result in the …
Protection of mammalian cells against chemotherapeutic agents thiotepa, 1, 3-N, N′-bis (2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base …
Y Xu, WK Hansen, TA Rosenquist, DA Williams… - … of Pharmacology and …, 2001 - ASPET
Chemotherapeutic agents used in the treatment of cancer often lead to dose-limiting bone
marrow suppression and may initiate secondary leukemia. N, N′, N" …
marrow suppression and may initiate secondary leukemia. N, N′, N" …