Decoding the Impact of Tumor Microenvironment in Osteosarcoma Progression and Metastasis

BK Nirala, T Yamamichi, DI Petrescu, TN Shafin… - Cancers, 2023 - mdpi.com
Simple Summary Osteosarcoma (OS) is the most common bone tumor in the pediatric
population. Currently, no effective molecularly targeted therapies are available for OS. The …

The Role of Macrophages in Sarcoma Tumor Microenvironment and Treatment

AE Zając, AM Czarnecka, P Rutkowski - Cancers, 2023 - mdpi.com
Simple Summary Soft tissue and bone sarcomas belong to a group of rare and malignant
tumors. The treatment of these tumors is very complex and depends on their specific …

Efficient and targeted siRNA delivery to M2 macrophages by smart polymer blends for M1 macrophage repolarization as a promising strategy for future cancer …

DC Jürgens, B Winkeljann… - ACS Biomaterials …, 2023 - ACS Publications
Cancer remains an issue on a global scale. It is estimated that nearly 10 million people
succumbed to cancer worldwide in 2020. New treatment options are urgently needed. A …

Overexpression of AXL on macrophages associates with disease severity and recurrence in chronic rhinosinusitis with nasal polyps

T Wang, Y Chen, R Gao, J Shui, B Xie - International Immunopharmacology, 2023 - Elsevier
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by high
tissue heterogeneity and risk of postoperative recurrence, but the underlying mechanisms …

[HTML][HTML] A bioactive nanocomposite integrated specific TAMs target and synergistic TAMs repolarization for effective cancer immunotherapy

W Gu, W Guo, Z Ren, Y Zhang, M Han, Q Zhao, Y Gao… - Bioactive Materials, 2024 - Elsevier
Reactive oxygen species (ROS) generated from photosensitizers exhibit great potential for
repolarizing immunosuppressive tumor-associated macrophages (TAMs) toward the anti …

A Disulfidptosis-Related Gene Signature Associated with Prognosis and Immune Cell Infiltration in Osteosarcoma

P Chen, J Shen - Bioengineering, 2023 - mdpi.com
Osteosarcoma (OS) stands as a leading aggressive bone malignancy that primarily affects
children and adolescents worldwide. A recently identified form of programmed cell death …

Manganese (III) Phthalocyanine Complex Nanoparticle-Loaded Glucose Oxidase to Enhance Tumor Inhibition through Energy Metabolism and Macrophage …

Z Liu, C Li, Y Cao, X Xu, Z Zhou, J Du… - ACS Applied Bio …, 2024 - ACS Publications
Elevated levels of reactive oxygen species (ROS) have demonstrated efficacy in eliminating
tumor cells by modifying the tumor microenvironment and inducing the polarization of tumor …

Exploration of altered miRNA expression and function in MSC-derived extracellular vesicles in response to hydatid antigen stimulation

X Wang, W Mijiti, Q Jia, Z Yi, J Ma, Z Zhou… - Frontiers in …, 2024 - frontiersin.org
Background Hydatid disease is caused by Echinococcus parasites and can affect various
tissues and organs in the body. The disease is characterized by the presence of hydatid …

[HTML][HTML] Hydroxysafflor yellow A induced ferroptosis of Osteosarcoma cancer cells by HIF-1α/HK2 and SLC7A11 pathway

Y Zhu, L Yang, Y Yu, Y Xiong, P Xiao, X Fu… - Oncology …, 2024 - ncbi.nlm.nih.gov
Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal
prognosis. Since there is no permanent therapy for this condition, it is necessary to develop …

Resolvin D2 attenuates LPS‐induced macrophage exhaustion

CM Padovani, RM Wilson, A Rodriguez… - The FASEB …, 2024 - Wiley Online Library
Early in sepsis, a hyperinflammatory response is dominant, but later, an immunosuppressive
phase dominates, and the host is susceptible to opportunistic infections. Anti‐inflammatory …