There is considerable interest in the development of membrane mimetics to study the
structure, dynamics and function of membrane proteins. Polymer nanodiscs have been …

The last∼ 25 years has seen mass spectrometry (MS) emerge as an integral method in the
structural biology toolkit. In particular, MS has enabled the structural characterization of …

Membrane proteins (MPs) are the gatekeepers between different biological compartments
separated by lipid bilayers. Being receptors, channels, transporters, or primary pumps, they …

Lipid nanodiscs formed by mixtures of styrene maleic acid (SMA) copolymers and lipid
membranes are important tools for studying membrane proteins in many biotechnological …

Nanoparticles assembled with poly (styrene-maleic acid) copolymers, identified in the
literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane …

Polymer stabilized nanodiscs are self-assembled structures composed of a polymer belt that
wraps around a segment of lipid bilayer, and as such are capable of encapsulating …

Membrane proteins (MPs) need to be extracted from biological membranes and purified in
their native state for most structural and functional in vitro investigations. Amphiphilic …

Membrane proteins (MPs) play a pivotal role in cellular function and are therefore
predominant pharmaceutical targets. Although detailed understanding of MP structure and …

Targeting of extracellular protein–protein interactions (PPI) is emerging as a major
application for de novo discovered macrocyclic peptides. Modern discovery platforms can …

The ability of amphipathic polymers to self-assemble with lipids and form nanodiscs has
been a boon for the field of functional reconstitution of membrane proteins. In a field …