Endosomal escape pathways for delivery of biologicals
Despite continuous improvements in delivery systems, the development of methods for
efficient and specific delivery of targeted therapeutic agents still remains an issue in …
efficient and specific delivery of targeted therapeutic agents still remains an issue in …
Strategies in the design of endosomolytic agents for facilitating endosomal escape in nanoparticles
Nanoparticles (NPs) are one of the leading and promising technologies for gene and drug
delivery. However, despite continuous advancements in the delivery of NPs, endosomal …
delivery. However, despite continuous advancements in the delivery of NPs, endosomal …
An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages
JM Silverman, J Clos, CC de'Oliveira… - Journal of cell …, 2010 - journals.biologists.com
Specialized secretion systems are used by numerous bacterial pathogens to export
virulence factors into host target cells. Leishmania and other eukaryotic intracellular …
virulence factors into host target cells. Leishmania and other eukaryotic intracellular …
Ribosome-inactivating proteins: current status and biomedical applications
M Puri, I Kaur, MA Perugini, RC Gupta - Drug discovery today, 2012 - Elsevier
Ribosome-inactivating proteins (RIPs) are mainly present in plants and function to inhibit
protein synthesis through the removal of adenine residues from eukaryotic ribosomal RNA …
protein synthesis through the removal of adenine residues from eukaryotic ribosomal RNA …
Ribosome-inactivating proteins: Potent poisons and molecular tools
MJ Walsh, JE Dodd, GM Hautbergue - Virulence, 2013 - Taylor & Francis
Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been
shown to be catalytic toxins that irreversibly inactivate protein synthesis. Elucidation of …
shown to be catalytic toxins that irreversibly inactivate protein synthesis. Elucidation of …
[HTML][HTML] Ribosome-inactivating proteins: from plant defense to tumor attack
M de Virgilio, A Lombardi, R Caliandro, MS Fabbrini - Toxins, 2010 - mdpi.com
Ribosome-inactivating proteins (RIPs) are EC3. 2.32. 22 N-glycosidases that recognize a
universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single …
universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single …
[HTML][HTML] Saporin-S6: a useful tool in cancer therapy
Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as
saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and …
saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and …
Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy
R Gilabert-Oriol, A Weng… - Current …, 2014 - ingentaconnect.com
The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …
[HTML][HTML] Plant ribosome-inactivating proteins: Progesses, challenges and biotechnological applications (and a few digressions)
MS Fabbrini, M Katayama, I Nakase, R Vago - Toxins, 2017 - mdpi.com
Plant ribosome-inactivating protein (RIP) toxins are EC3. 2.2. 22 N-glycosidases, found
among most plant species encoded as small gene families, distributed in several tissues …
among most plant species encoded as small gene families, distributed in several tissues …