5‐Fluorouracil (5‐FU) is dosed by body surface area, a practice unable to reduce the
interindividual variability in exposure. Endorsed by the International Association of …

Previous studies have suggested that a delay in initiating clozapine is one of the predictors
of outcomes in treatment-resistant schizophrenia (TRS). However, whether there is a critical …

ABSTRACT Introduction: Second-generation antipsychotics (SGAs) are frequently co-
prescribed with drug metabolic inducers and inhibitors. SGA pharmacokinetic drug-drug …

A significant number of patients with schizophrenia do not respond adequately to an initial
antipsychotic trial. As first step within a treatment algorithm for therapy-refractory …

Objective Treatment resistance is a challenge for the management of schizophrenia. It is not
always clear whether inadequate response is secondary to medication ineffectiveness, as …

Seizures are a known adverse effect of clozapine therapy. The literature varies on incidence
rates of seizures, secondary to varying time frames in which each seizure occurred. Tonic …

A new analyte separation and preconcentration method for the trace determination of
antidepressant drugs, Fluoxetine (FLU) and Citalopram (CIT) in urine and wastewaters, was …

Epigenetic processes, such as DNA methylation, and molecular chaperones, including
FK506-binding protein 51 (FKBP51), are independently implicated in stress-related mental …

Advanced stages of Parkinson's disease (advPD) still impose a challenge in terms of
classification and related stage-adapted treatment recommendations. Previous concepts …

Osteoarthritis (OA) is a debilitating joint disease characterized by progressive cartilage
degeneration, with no available disease-modifying therapy. OA is driven by pathological …