Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine
Epigenetic processes, such as DNA methylation, and molecular chaperones, including
FK506-binding protein 51 (FKBP51), are independently implicated in stress-related mental …
FK506-binding protein 51 (FKBP51), are independently implicated in stress-related mental …
[HTML][HTML] Pathogenesis and treatment of depression: role of diet in prevention and therapy
W Mrozek, J Socha, K Sidorowicz, A Skrok, A Syrytczyk… - Nutrition, 2023 - Elsevier
In recent years, there has been a significant increase in depression, which is related to,
among other things, the COVID-19 pandemic. Depression can be fatal if not treated or if …
among other things, the COVID-19 pandemic. Depression can be fatal if not treated or if …
[HTML][HTML] Revealing the reporting disparity: VigiBase highlights underreporting of clozapine in other Western European countries compared to the UK
Background Pharmacovigilance studies indicate clozapine history is marked by adverse
drug reactions (ADRs). Objective In a 2021 article, the United Kingdom (UK) had> 90% of …
drug reactions (ADRs). Objective In a 2021 article, the United Kingdom (UK) had> 90% of …
Therapeutic reference ranges for psychotropic drugs: a protocol for systematic reviews
Background: For many psychotropic drugs, monitoring of drug concentrations in the blood
(Therapeutic Drug Monitoring; TDM) has been proven useful to individualize treatments and …
(Therapeutic Drug Monitoring; TDM) has been proven useful to individualize treatments and …
Mechanisms of antidepressant resistance
Depression is one of the most frequent and severe mental disorder. Since the discovery of
antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds …
antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds …
Novel treatment options in depression and psychosis
E Ceskova, P Silhan - Neuropsychiatric disease and treatment, 2018 - Taylor & Francis
In spite of tremendous development in central nervous system research, current treatment is
suboptimal, especially in severe mental disorders. In medicine, there are two main methods …
suboptimal, especially in severe mental disorders. In medicine, there are two main methods …
Pharmacogenetics and outcome with antipsychotic drugs
Antipsychotic medications are the gold-standard treatment for schizophrenia, and are often
prescribed for other mental conditions. However, the efficacy and side-effect profiles of these …
prescribed for other mental conditions. However, the efficacy and side-effect profiles of these …
[HTML][HTML] Chronic and treatment resistant depression: diagnosis and stepwise therapy
Chronic and Treatment Resistant Depression - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation …
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation …
Treatment with antipsychotics in pregnancy: changes in drug disposition
Although pregnancy is known to cause changes in drug pharmacokinetics, little is known
about its impact on serum levels of antipsychotics. In this study we retrospectively assessed …
about its impact on serum levels of antipsychotics. In this study we retrospectively assessed …
Clozapine and therapeutic drug monitoring: is there sufficient evidence for an upper threshold?
Rationale Clozapine levels are advocated in the monitoring of patients on this drug and
have now been used for a number of years. A safety-related threshold has also been …
have now been used for a number of years. A safety-related threshold has also been …