Therapeutic Drug monitoring (TDM) is a multidisciplinary endeavor encompassing skills of
the laboratory, clinical pharmacologists and physicians aimed at providing the best possible …

Background Whether or not second-generation antipsychotics (SGAs) represent an
advantage over first-generation antipsychotics (FGAs) in the treatment of schizophrenia is …

Both inflammation and smoking can influence a drug's pharmacokinetic properties, ie, its
liberation, absorption, distribution, metabolism, and elimination. Depending on, eg …

Schizophrenia is a chronic medical condition with periods of remission and relapses over a
patient's lifetime. Antipsychotic medications represent the mainstay of treatment for this …

Background Obesity is one of the most prevalent somatic comorbidities of Major Depressive
Disorder (MDD). We aimed to investigate the relationship between body mass index (BMI) …

Objectives: More than 40 drugs are available to treat affective disorders. Individual selection
of the optimal drug and dose is required to attain the highest possible efficacy and …

Growing evidence supports a mutual relationship between inflammation and major
depression. A variety of mechanisms are outlined, indicating how inflammation may be …

Fixed oral doses of clozapine produce up to 45-fold interindividual variability among its
serum levels in patients with treatment-resistant schizophrenia. Although the relationship …

Sertraline, a selective serotonin reuptake inhibitor (SSRI), is commonly prescribed to treat
several psychiatric disorders including major depressive disorder (MDD), panic, generalized …

Objective: To meta-analyze randomized controlled trials (RCTs) for the efficacy and safety of
adjunctive antiepileptic drugs (AEDs) to augment clozapine therapy for treatment-resistant …