[HTML][HTML] Microglia heterogeneity in the single-cell era

T Masuda, R Sankowski, O Staszewski, M Prinz - Cell reports, 2020 - cell.com
Microglia are resident immune cells in the central nervous system (CNS) that are capable of
carrying out prominent and various functions during development and adulthood under both …

[HTML][HTML] Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

AG Spiteri, CL Wishart, R Pamphlett, G Locatelli… - Acta …, 2022 - Springer
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

TC Theoharides, C Cholevas, K Polyzoidis… - Biofactors, 2021 - Wiley Online Library
COVID‐19 leads to severe respiratory problems, but also to long‐COVID syndrome
associated primarily with cognitive dysfunction and fatigue. Long‐COVID syndrome …

[HTML][HTML] TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

F Cignarella, F Filipello, B Bollman, C Cantoni… - Acta …, 2020 - Springer
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are …

[HTML][HTML] Potential implications of quercetin in autoimmune diseases

P Shen, W Lin, L Han, K Qin, Y Huang… - Frontiers in Immunology, 2021 - frontiersin.org
Autoimmune diseases are a worldwide health problem with growing rates of morbidity, and
are characterized by breakdown and dysregulation of the immune system. Although their …

The role of glial cells in multiple sclerosis disease progression

LM Healy, JA Stratton, T Kuhlmann… - Nature Reviews Neurology, 2022 - nature.com
Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …

Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

AG Wu, XG Zhou, G Qiao, LU Yu, Y Tang, LU Yan… - Ageing research …, 2021 - Elsevier
Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …

[HTML][HTML] The role of GPNMB in inflammation

M Saade, G Araujo de Souza, C Scavone… - Frontiers in …, 2021 - frontiersin.org
Inflammation is a response to a lesion in the tissue or infection. This process occurs in a
specific manner in the central nervous system and is called neuroinflammation, which is …

[HTML][HTML] Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

S Werneburg, J Jung, RB Kunjamma, SK Ha… - Immunity, 2020 - cell.com
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous
system. While work has focused on myelin and axon loss in MS, less is known about …

Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function

Y Zhang, JT Bailey, E Xu, K Singh, M Lavaert… - Nature …, 2022 - nature.com
Increasing evidence indicates close interaction between immune cells and the brain,
revising the traditional view of the immune privilege of the brain. However, the specific …