Molecular targeting therapies for neuroblastoma: Progress and challenges

A Zafar, W Wang, G Liu, X Wang, W Xian… - Medicinal research …, 2021 - Wiley Online Library
There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …

[HTML][HTML] Recent advances in PROTACs for drug targeted protein research

T Yao, H Xiao, H Wang, X Xu - International Journal of Molecular …, 2022 - mdpi.com
Proteolysis-targeting chimera (PROTAC) is a heterobifunctional molecule. Typically,
PROTAC consists of two terminals which are the ligand of the protein of interest (POI) and …

[HTML][HTML] Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

A Osipyan, D Chen, FJ Dekker - Drug discovery today, 2021 - Elsevier
Highlights•Macrophage migration inhibitory factor (MIF) plays a crucial role in cancer and
inflammatory diseases.•Epigenetic mechanisms are involved in MIF-mediated …

Proteolysis targeting chimera (PROTAC) for macrophage migration inhibitory factor (MIF) has anti‐proliferative activity in lung cancer cells

Z Xiao, S Song, D Chen, R van Merkerk… - Angewandte Chemie …, 2021 - Wiley Online Library
Macrophage migration inhibitory factor (MIF) is involved in protein‐protein interactions that
play key roles in inflammation and cancer. Current strategies to develop small molecule …

[HTML][HTML] OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases

M Thiele, SC Donnelly, RA Mitchell - Journal for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with a pleiotropic
spectrum of biological functions implicated in the pathogenesis of cancer and inflammatory …

Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer …

Z Xiao, A Osipyan, S Song, D Chen… - Journal of Medicinal …, 2022 - ACS Publications
The homologous cytokines macrophage migration inhibitory factor (MIF) and d-dopachrome
tautomerase (d-DT or MIF2) play key roles in cancers. Molecules binding to the MIF …

Targeting RAS in neuroblastoma: Is it possible?

L Lin, L Miao, H Lin, J Cheng, M Li, Z Zhuo… - Pharmacology & …, 2022 - Elsevier
Neuroblastoma is a common solid tumor in children and a leading cause of cancer death in
children. Neuroblastoma exhibits genetic, morphological, and clinical heterogeneity that …

A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma

HF Zhang, A Delaidelli, S Javed, B Turgu… - Science …, 2023 - science.org
MYCN amplification (MNA) is a defining feature of high-risk neuroblastoma (NB) and
predicts poor prognosis. However, whether genes within or in close proximity to the MYCN …

[PDF][PDF] A Case control study to determine Macrophage migration inhibitor, and N-telopeptides of type I bone collagen Levels in the sera of osteoporosis patients

LO Farhan, EM Taha, AM Farhan - Baghdad Science Journal, 2022 - iasj.net
This study focused on determining the markers of Macrophage migration inhibitor (MIF), as
well as the N-telopeptides of type I bone collagen (NTX), and some other parameters …

Macrophage migration inhibitory factor (MIF) and its homologue d-dopachrome tautomerase (DDT) inversely correlate with inflammation in discoid lupus …

R Caltabiano, R De Pasquale, E Piombino, G Campo… - Molecules, 2021 - mdpi.com
Discoid Lupus Erythematosus (DLE) is a chronic cutaneous disease of unknown etiology
and of immunoinflammatory origin that is characterized by inflammatory plaques and may …