Molecular targeting therapies for neuroblastoma: Progress and challenges
There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …
[HTML][HTML] Recent advances in PROTACs for drug targeted protein research
Proteolysis-targeting chimera (PROTAC) is a heterobifunctional molecule. Typically,
PROTAC consists of two terminals which are the ligand of the protein of interest (POI) and …
PROTAC consists of two terminals which are the ligand of the protein of interest (POI) and …
[HTML][HTML] Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation
Highlights•Macrophage migration inhibitory factor (MIF) plays a crucial role in cancer and
inflammatory diseases.•Epigenetic mechanisms are involved in MIF-mediated …
inflammatory diseases.•Epigenetic mechanisms are involved in MIF-mediated …
Proteolysis targeting chimera (PROTAC) for macrophage migration inhibitory factor (MIF) has anti‐proliferative activity in lung cancer cells
Z Xiao, S Song, D Chen, R van Merkerk… - Angewandte Chemie …, 2021 - Wiley Online Library
Macrophage migration inhibitory factor (MIF) is involved in protein‐protein interactions that
play key roles in inflammation and cancer. Current strategies to develop small molecule …
play key roles in inflammation and cancer. Current strategies to develop small molecule …
[HTML][HTML] OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases
M Thiele, SC Donnelly, RA Mitchell - Journal for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with a pleiotropic
spectrum of biological functions implicated in the pathogenesis of cancer and inflammatory …
spectrum of biological functions implicated in the pathogenesis of cancer and inflammatory …
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer …
The homologous cytokines macrophage migration inhibitory factor (MIF) and d-dopachrome
tautomerase (d-DT or MIF2) play key roles in cancers. Molecules binding to the MIF …
tautomerase (d-DT or MIF2) play key roles in cancers. Molecules binding to the MIF …
Targeting RAS in neuroblastoma: Is it possible?
L Lin, L Miao, H Lin, J Cheng, M Li, Z Zhuo… - Pharmacology & …, 2022 - Elsevier
Neuroblastoma is a common solid tumor in children and a leading cause of cancer death in
children. Neuroblastoma exhibits genetic, morphological, and clinical heterogeneity that …
children. Neuroblastoma exhibits genetic, morphological, and clinical heterogeneity that …
A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma
MYCN amplification (MNA) is a defining feature of high-risk neuroblastoma (NB) and
predicts poor prognosis. However, whether genes within or in close proximity to the MYCN …
predicts poor prognosis. However, whether genes within or in close proximity to the MYCN …
[PDF][PDF] A Case control study to determine Macrophage migration inhibitor, and N-telopeptides of type I bone collagen Levels in the sera of osteoporosis patients
This study focused on determining the markers of Macrophage migration inhibitor (MIF), as
well as the N-telopeptides of type I bone collagen (NTX), and some other parameters …
well as the N-telopeptides of type I bone collagen (NTX), and some other parameters …
Macrophage migration inhibitory factor (MIF) and its homologue d-dopachrome tautomerase (DDT) inversely correlate with inflammation in discoid lupus …
R Caltabiano, R De Pasquale, E Piombino, G Campo… - Molecules, 2021 - mdpi.com
Discoid Lupus Erythematosus (DLE) is a chronic cutaneous disease of unknown etiology
and of immunoinflammatory origin that is characterized by inflammatory plaques and may …
and of immunoinflammatory origin that is characterized by inflammatory plaques and may …