A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …

Oxidative stress is defined as an imbalance between production of free radicals and reactive
metabolites or [reactive oxygen species (ROS)] and their elimination by through protective …

Heart failure (HF) is a major health-care problem and the prognosis of affected patients is
poor. HF often coexists with a number of comorbidities of which declining renal function is of …

Type 2 diabetes is a redox disease. Oxidative stress and chronic inflammation induce a
switch of metabolic homeostatic set points, leading to glucose intolerance. Several diabetes …

Cardiac remodeling is defined as a group of molecular, cellular and interstitial changes that
manifest clinically as changes in size, mass, geometry and function of the heart after injury …

Cardiovascular diseases are the leading cause of death worldwide. Endothelial dysfunction,
inflammation and oxidative stress are at the forefront in the onset and development of …

Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the
impairment of redox homeostasis and cellular death. Iron overload is often associated with …

The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …

Abstract Cardiovascular (CV) disease (CVD) is the leading global cause of mortality, being
responsible for 46% of non-communicable disease deaths. It has been estimated that about …